156369-00-5

Basic information

• Product Name: (2E,4E)-8,10,12-trihydroxydodeca-2,4-dienoic acid
• Synonyms: YF 0200R-B
• CAS NO: 156369-00-5
• Molecular Formula: C₁₂H₂₀O₅
• Molecular Weight: 244.2842
• Mol File: 156369-00-5.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 529.4°C at 760 mmHg
• Flash Point: 288.1°C
• Density: 1.21g/cm³
• Vapor Pressure: 2.03E-13mmHg at 25°C
• Refractive Index: 1.545
• CAS DataBase Reference: (2E,4E)-8,10,12-trihydroxydodeca-2,4-dienoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (2E,4E)-8,10,12-trihydroxydodeca-2,4-dienoic acid(156369-00-5)
• EPA Substance Registry System: (2E,4E)-8,10,12-trihydroxydodeca-2,4-dienoic acid(156369-00-5)

Safety Data

• Hazardous Substances Data: 156369-00-5(Hazardous Substances Data)

Upstream product

• 1106401-93-7 C₁₅H₃₀O₄Si 
• 1291066-68-6 (1S)-1-((4R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-((2S)-oxiran-2-yl)-ethyl tert-butyldimethyl-silyl ether 

Relevant articles and documents

Synthesis and configurations of YF-0200R A and B

Two natural unsaturated fatty acids with aspargyl protease inhibition activity were synthesized for the first time. The stereogenic centers were installed by using Brown asymmetric allylation or chiral building blocks derived from d-glucose, respectively. The conjugate diene unit was introduced via an HWE reaction. The geometry of the C-C double bonds was clearly shown to be (E) by 1H NMR in C6D6. The spectroscopic data for the synthetic samples were in excellent consistency with those reported for the corresponding natural ones. The optical rotations were also compatible with those for the natural ones. The absolute configurations for natural YF-0200R A and B thus could be reliably assigned as (8S) and (8S,10S), respectively.