156382-73-9Relevant academic research and scientific papers
Nickel-catalyzed hydroalkylation of 1,3-dienes with malonates using a homoallyl carbonate as the 1,3-diene and hydride source
Tsuji, Hiroaki,Takahashi, Yoshiyuki,Kawatsura, Motoi
, (2021)
The use of a malonate nucleophile in the transition metal-catalyzed hydroalkylation of 1,3-dienes remains immature. Herein, we report the nickel-catalyzed hydroalkylation of 1,3-dienes with malonates using a homoallyl carbonate as the 1,3-diene and hydride source. A broad range of homoally carbonates and malonate derivatives were well tolerated under a Ni/DPEphos catalyst system, providing the corresponding 1,2-hydroalkylation products in 40–94% yields with excellent regioselectivity (32 examples). We also suggested the possible reaction mechanism for the nickel-catalyzed hydroalkylation of in situ generated 1,3-dienes with malonates.
Iron-catalyzed nucleophilic substitution of allylic acetate
Akermark, Bjoern,Sjoegren, Magnus P. T.
, p. 2641 - 2646 (2008/09/19)
The combination of diiron nonacarbonyl and dimethylamine gives an active catalyst for displacement of allylic acetate by diethyl methylmalonate. It was found that among a series of amines, only dimethylamine and morpholine were efficient promoters of the
