156384-41-7Relevant academic research and scientific papers
SYNTHESE D'UN ANALOGUE DU FOSTEDIL: LE DIETHYL 4-(1,2,3-DIAZAPHOSPHOL-5-YL)BENZYLPHOSPHONATE. ETUDE DE SON ACTIVITE INHIBITRICE DU TRANSPORT CALCIQUE A TRAVERS LES MEMBRANES BIOLOGIQUES
Rodi, Youssef Kandri,Lopez, Lucien,Bellan, Jacques,Barrans, Jean,Essassi, El Moktar
, p. 225 - 231 (2007/10/02)
We describe a four step synthesis of dicoordinated phosphorus Fostedil analogues: the diethyl-4(1,2,3-diazaphosphol-5-yl)benzylphosphonates 6, in which the benzothiazole Fostedil group is replaced by a 1,2,3 diazaphosphole ring.Inhibitive activity of calcium transfert, through biological membranes, of compounds 6 is weak. Key words: 1,2,3-Diazaphospholes; Fostedil analogues, calcium antagonist.
