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6H-Purine-6-thione, 1,9-dihydro-9-b-L-ribofuranosyl-, also known as 6-mercaptopurine riboside or 6-MP riboside, is a chemical compound derived from the purine family. It is a nucleoside analog, which means it is structurally similar to a natural nucleoside but with a modified base or sugar component. In this case, the modification is the presence of a sulfur atom in place of an oxygen atom at the 6th position of the purine ring, and it is attached to a ribose sugar. 6H-Purine-6-thione,1,9-dihydro-9-b-L-ribofuranosyl- is of interest in medicinal chemistry due to its potential therapeutic applications, particularly as an antineoplastic agent. It is used in the treatment of certain types of cancer, such as acute lymphoblastic leukemia, by interfering with DNA synthesis and function, thus inhibiting the growth of cancer cells. The compound's activity is based on its ability to incorporate into DNA, where it can cause errors during replication, leading to cell death.

15639-75-5

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15639-75-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 15639-75-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,6,3 and 9 respectively; the second part has 2 digits, 7 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 15639-75:
(7*1)+(6*5)+(5*6)+(4*3)+(3*9)+(2*7)+(1*5)=125
125 % 10 = 5
So 15639-75-5 is a valid CAS Registry Number.

15639-75-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name 9-[3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-3H-purine-6-thione

1.2 Other means of identification

Product number -
Other names 9-pentofuranosyl-3,9-dihydro-purine-6-thione

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15639-75-5 SDS

15639-75-5Downstream Products

15639-75-5Relevant academic research and scientific papers

Heterocyclic compound containing SCF3 or SeCF3, and preparation method thereof

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Paragraph 0097-0100, (2020/07/12)

The invention discloses a heterocyclic compound containing SCF3 or SeCF3, and a preparation method thereof. The preparation method comprises: dissolving a chlorinated heterocyclic compound 1 in an EtOH solution, adding 1.0-2.0 equivalent weight of thiourea or selenourea, then stirring for 1-8 hours at 50-120 DEG C, and reacting to obtain a compound 2; and dissolving the compound 2 in an Acetone orEA solution, adding 2.0-4.0 equivalent weight of CF3SO2Na and 0.2-0.4 equivalent weight of a Cu salt, adding 2.0-4.0 equivalent weight of a tBuOOH solution in a dropwise manner, and reacting at 25-40DEG C for 1.0-2.0 hours to obtain a compound 3, namely the required SCF3 or SeCF3-containing heterocyclic compound. According to the invention, the synthesized compound has huge potential in the aspect of treating diseases; and according to the synthetic route provided by the invention, amplification can be realized in each step, the yield can reach 85%, the synthetic route provided by the invention brings a simpler and more effective way for synthesis of compounds with biological activity, the yield is high, large-scale preparation can be realized, and the synthetic route has a very wide application prospect.

Thio- or seleno-amide compound and preparation method thereof

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Paragraph 0058-0061, (2020/07/24)

The invention discloses a thio- or seleno-amide compound and a preparation method thereof. The preparation method comprises the following steps of dissolving a chlorinated aromatic heterocyclic compound 1 in an EtOH solution, adding 1.0-2.0 times of equivalent thiourea or selenourea, stirring at 50-120 DEG C for 1-8 hours, and reacting to obtain a compound 2, namely the required thio- or seleno-amide compound. Each step of the synthetic route can be amplified, the yield can reach 85 percent, the synthesized compound provides a medical intermediate for synthesizing purine derivatives containingSCF3 or SeCF3, the synthetic route provided by the invention brings a simpler and more effective way for synthesizing compounds with biological activity, the yield is high, large-scale preparation can be realized, and the application prospect is very wide.

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