1563931-94-1

Basic information

• Product Name: 3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)thiazolidine-2,4-dione
• Synonyms: 3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)thiazolidine-2,4-dione
• CAS NO: 1563931-94-1
• Molecular Weight: 293.319
• Mol File: 1563931-94-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)thiazolidine-2,4-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)thiazolidine-2,4-dione(1563931-94-1)
• EPA Substance Registry System: 3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)thiazolidine-2,4-dione(1563931-94-1)

Safety Data

• Hazardous Substances Data: 1563931-94-1(Hazardous Substances Data)

Upstream product

• 2295-31-0 thiazoline-2,4-dione 
• 204205-33-4 2-bromo-1-cyclopropyl-2-(2-fluorophenyl)ethanone 

Downstream Products

• 1563933-10-7 (Z)-5-benzylidene-3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)thiazolidine-2,4-dione 
• 1563934-60-0 (Z)-5-(4-chlorobenzylidene)-3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)thiazolidine-2,4-dione 
• 1563935-95-4 (Z)-3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5-(4-fluorobenzylidene)thiazolidine-2,4-dione 
• 1563936-66-2 (Z)-3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5-(4-hydroxybenzylidene)thiazolidine-2,4-dione 
• 1563936-90-2 (Z)-3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione 
• 1435516-23-6 (Z)-3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5-(4-(methylthio)benzylidene)thiazolidine-2,4-dione 
• 1563937-19-8 (Z)-3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5-(3,4-dihydroxybenzylidene)thiazolidine-2,4-dione 
• 1563937-35-8 (Z)-3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5-(3,4-dimethoxybenzylidene)thiazolidine-2,4-dione 
• 1563937-56-3 (Z)-3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5-(2,4,6-trimethoxybenzylidene)thiazolidine-2,4-dione 
• 1563937-83-6 (Z)-3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5-(3,4,5-trimethoxybenzylidene)thiazolidine-2,4-dione 
• 1563938-07-7 (Z)-5-(2-bromo-5-hydroxy-4-methoxybenzylidene)-3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)thiazolidine-2,4-dione 
• 1563938-16-8 (Z)-3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5-(4-(piperidin-1-yl)benzylidene)thiazolidine-2,4-dione 
• 1563938-48-6 (Z)-3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)-5-(thiophen-2-ylmethylene)thiazolidine-2,4-dione 
• 1563938-79-3 (Z)-5-((4-bromothiophen-2-yl)methylene)-3-(2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl)thiazolidine-2,4-dione 

Relevant articles and documents

Antimycobacterial evaluation of novel hybrid arylidene thiazolidine-2,4- diones

A series of novel hybrid heterocycles comprising arylidene thiazolidine-2,4-dione and 1-cyclopropyl-2-(2-fluorophenyl)ethanone were synthesized. These compounds were evaluated for their antimycobacterial activity against Mycobacterium tuberculosis H37Rv in High Throughput Screen. Most of the hybrid arylidene thiazolidine-2,4-diones displayed moderate to good activity with MIC of less than 50 μM. Compound 1m exhibited maximum potency being 5.87 fold more active at EC50 and 6.26 fold more active at EC90 than the standard drug pyrimethamine.