1564249-38-2Relevant academic research and scientific papers
Selective PKCδ Inhibitor B106 Elicits Uveal Melanoma Growth Inhibitory Effects Independent of Activated PKC Isoforms
Heijkants, Renier,Teunisse, Amina,De Vries, Jelle,Ovaa, Huib,Jochemsen, Aart
, p. 132 - 136 (2019)
In uveal melanoma (UM) cells, the protein kinase C (pathway) is almost generally constitutively activated as a result of an activating mutation in either the GNAQ or the GNA11 G-protein. A pan-PKC inhibitor, sotrastaurin (also named AEB071), is in clinica
