1564262-35-6

Basic information

• Product Name: C₂₁H₂₈Cl₂N₂O₃S
• CAS NO: 1564262-35-6
• Molecular Weight: 459.437
• Mol File: 1564262-35-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₁H₂₈Cl₂N₂O₃S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₁H₂₈Cl₂N₂O₃S(1564262-35-6)
• EPA Substance Registry System: C₂₁H₂₈Cl₂N₂O₃S(1564262-35-6)

Safety Data

• Hazardous Substances Data: 1564262-35-6(Hazardous Substances Data)

Upstream product

• 1564262-55-0 C₁₄H₂₂N₂O₂S 
• 927679-54-7 (1α,5α,6α)-3-(tert-butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid 
• 1234173-05-7 C₁₅H₂₂N₂O₂ 
• 871239-62-2 tert-butyl (1R,5S,6r)-6-cyano-3-azabicyclo[3.1.0]hexane-3-carboxylate 
• 1269429-62-0 (1R,5S)-6-carbamoyl-3-azabicyclo[3.1.0]hexane-3-carboxylic acid tert-butyl ester 
• 89-75-8 2,4-dichlorobenzoyl chloride 
• 134575-37-4 3-(tert-butyl) 6-ethyl (1R,5S,6r)-3-azabicyclo[3.1.0]hexane-3,6-dicarboxylate 

Relevant articles and documents

Novel GlyT1 inhibitor chemotypes by scaffold hopping. Part 1: Development of a potent and CNS penetrant [3.1.0]-based lead

This Letter describes the development and SAR of a novel series of GlyT1 inhibitors derived from a scaffold hopping approach that provided a robust intellectual property position, in lieu of a traditional, expensive HTS campaign. Members within this new [3.1.0]-based series displayed excellent GlyT1 potency, selectivity, free fraction, CNS penetration and efficacy in a preclinical model of schizophrenia (prepulse inhibition).