1564266-87-0

Basic information

• Product Name: (S)-N-Boc-3-hydroxyadamantylglycine-D-cis-4,5-methanoprolinamide
• Synonyms: (S)-N-Boc-3-hydroxyadamantylglycine-D-cis-4,5-methanoprolinamide
• CAS NO: 1564266-87-0
• Molecular Weight: 433.548
• Mol File: 1564266-87-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (S)-N-Boc-3-hydroxyadamantylglycine-D-cis-4,5-methanoprolinamide(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-N-Boc-3-hydroxyadamantylglycine-D-cis-4,5-methanoprolinamide(1564266-87-0)
• EPA Substance Registry System: (S)-N-Boc-3-hydroxyadamantylglycine-D-cis-4,5-methanoprolinamide(1564266-87-0)

Safety Data

• Hazardous Substances Data: 1564266-87-0(Hazardous Substances Data)

Upstream product

• 68766-96-1 ethyl (R)-2-pyrrolidone-5-carboxylate 

Relevant articles and documents

Synthesis and biological evaluation of all eight stereoisomers of DPP-IV inhibitor saxagliptin

All eight stereoisomers of saxagliptin have been synthesized and evaluated for their inhibitory activity against DPP-IV. It was unambiguously confirmed that the configuration of saxagliptin was critical to potent inhibition of DPP-IV. Docking study was performed to elucidate the configuration-activity relationship of saxagliptin stereoisomers. Tyr662 and Tyr470 have been suggested as the key residues of DPP-IV interacting with the inhibitors. This work provides valuable information for further inhibitor design against DPP-IV.