156440-96-9Relevant articles and documents
Synthesis and Antibacterial Activities of 4-Pyrrolidinylthio Carbapenems: Containing Heteroaromatics as a Side Chain
Cho, Han-Won,Oh, Chang-Hyun,Lee, Ju-Shin,Lee, Soo-Chul,Choi, Jung-Hoon,Cho, Jung-Hyuck
, p. 495 - 503 (2007/10/03)
The synthesis of a new series of 2-alkyl-4-pyrrolidinylthio-b-methylcarbapenems containing the substituted heteroaromatic moieties is described. Their in vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested. The effect of substituents on the nitrogen atoms at heteroaromatic rings was investigated. Particular compounds (14b, 14c) containing 3-methyl- and 3,5-dimethylpyrazolethio substituted moiety showed the most potent antibacterial activity.