15645-02-0Relevant academic research and scientific papers
Derivatives of indole. 143. Synthesis of photochromic derivatives of 2-arylindoles
Gogrichiani,Katsadze,Gavtadze,Samsoniya,Duerr
, p. 1271 - 1278 (2007/10/03)
New derivatives of 2-arylindoles containing (4-pyridyl)alkyl substituents at various positions of the pyrrole ring were synthesized. They react with 2,3 dimethoxycarbonylspirofluorenylcyclopropene with the formation of light-sensitive systems belonging to the photochromic dihydroindolizine class.
3-(4-Piperidinylalkyl)indoles, Selective Inhibitors of Neuronal 5-Hydroxytryptamine Uptake
Gueremy, Claude,Audiau, Francois,Champseix, Alain,Uzan, Andre,Fur, Gerard Le,Rataud, Jean
, p. 1306 - 1310 (2007/10/02)
A series 3-(4-piperidinylalkyl)indoles was synthesized and tested as uptake inhibitors of biogenic amines.Some of these compounds are potent and very selective in blocking the 5-hydroxytryptamine (5-HT) uptake, as evidenced by biochemical data and behavioral tests.A discussion on structure-activity relationships is given.The most interesting member of the series, indalpine, 3-indole (1), was selected for clinical studies.
