156481-74-2

Usage

Chemical Properties

White powder

InChI:InChI=1/C21H17NO2/c23-20-22-19(16-10-4-1-5-11-16)21(24-20,17-12-6-2-7-13-17)18-14-8-3-9-15-18/h1-15,19H,(H,22,23)/t19-/m1/s1

Upstream product

• 60539-17-5 (R)-(+)-2-amino-1,1,2-triphenylethanol 
• 503-38-8 trichloromethyl chloroformate 
• 19883-41-1 D-phenylglycine methyl ester hydrochloride 
• 62183-23-7 4,5,5-triphenyl-oxazolidin-2-one 
• 141190-94-5 (R)-N-(tert-butoxycarbonyl)phenylglycine methyl ester 
• 875-74-1 (R)-phenylglycine 
• 223906-34-1 (2R)-N-Boc-2-amino-1,1,2-triphenylpropanol 

Downstream Products

• 223906-51-2 (4R)-N-Propionyl-4,5,5-triphenyloxazolidin-2-one 
• 345905-08-0 (R)-3-methylsulfanylmethyl-4,5,5-triphenyl-oxazolidin-2-one 
• 156481-77-5 (4R)-4,5,5-triphenyl-3-vinyl-2-oxazolidinone 
• 156481-81-1 (R)-3-((1R,2S)-2-Fluoro-cyclopropyl)-4,5,5-triphenyl-oxazolidin-2-one 
• 1215291-27-2 (R)-3-[(E)-but-2-enoyl]-4,5,5-triphenyloxazolidin-2-one 
• 1215291-30-7 (R)-4,5,5-triphenyl-3-[(E)-3-phenylprop-2-enoyl]oxazolidin-2-one 
• 1393834-15-5 (4R,Z)-N-(4'-benzyloxy-but-3'-enoyl)-4,5,5-triphenyloxazolidin-2-one 
• 1393834-02-0 (2'S,4R,Z)-N-(4'-benzyloxyl-2-methylbut-3'-enoyl)-4,5,5-triphenyloxazolidin-2-one 
• 1393833-98-1 (2'R,4R,Z)-3-(4'-benzyloxyl-2'-allylbut-3'-enoyl)-4,5,5-triphenyloxazolidinone 

Relevant academic research and scientific papers

Synthesis and application of N-3,5-dinitrobenzoyl and C3 symmetric diastereomeric chiral stationary phases

Three diastereomeric chiral compounds, namely, (R,R)-(+)-2-amino-1,2-diphenylethanol, (1S,2R)-(+)-2-amino-1,2-diphenylethanol, and (1R,2R)-(+)-1,2-diphenylethylenediamine were used as starting materials for preparing three N-3,5-dinitrobenzoyl derivative

Synthesis of new C3 symmetric amino acid- and aminoalcohol-containing chiral stationary phases and application to HPLC enantioseparations

We recently reported a new C3-symmetric (R)-phenylglycinol N-1,3,5-benzenetricarboxylic acid-derived chiral high-performance liquid chromatography (HPLC) stationary phase (CSP 1) that demonstrated better results as compared to a previously described N-3,5-dintrobenzoyl (DNB) (R)-phenylglycinol-derived CSP. Over a decade ago, (S)-leucinol, (R)-phenylglycine, and (S)-leucine derivatives were used as the starting materials of 3,5-DNB-based Pirkle-type CSPs for chiral separation. In this study, three new C3-symmetric CSPs (CSP 2, 3, and 4) were prepared by combining the ideas and results mentioned above. Here we describe the synthetic procedures and applications of the new C3-symmetric CSPs (CSP 2–CSP 4).

Remarkably efficient charcoal-promoted ring-closing carbonylations

An efficient, versatile and practical gram-scale preparation of oxazolidinone, imidazolidinone and dioxolanone is achieved. Georg Thieme Verlag Stuttgart.

Asymmetric alkylations using SuperQuat auxiliaries - An investigation into the synthesis and stability of enolates derived from 5,5-disubstituted oxazolidin-2-ones

Studies on the alkylation of enolates derived from a range of N-acyl-5,5-dimethyloxazolidin-2-ones and N-acyl-5,5-diphenyloxazolidin-2-ones reveal that high yields and high diastereoselectivities are best obtained when homochiral 4-isopropyl-5,5-dimethyloxazolidin-2-one is employed as a chiral auxiliary.

Synthetic Studies on the Key Component of the New Generation of Quinolonecarboxylic Acid, DU-6859. 2. Asymmetric Synthesis of (1R,2S)-2-Fluorocyclopropylamine

The title synthesis was achieved by featuring diastereoface-selective cyclopropanation of (4R,5S)-4,5-diphenyl-3-vinyl-2-oxazolidinone and its related compounds, the chiral conformationally rigid N-vinylcarbamates, with zinc-monofluorocarbenoid, followed