156488-57-2Relevant academic research and scientific papers
IGF-1R SIGNALING PATHWAY INHIBITORS USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
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Paragraph 0251; 0252; 0253; 0254; 0255; 0256; 0257, (2016/07/05)
The present invention provides compounds acting as Insulin/IGF signaling modulators useful in the treatment of neurodegenerative diseases and disorders. The invention provides pharmaceutical compositions including such compounds, and methods of using thes
Modular Approach to 9-Monosubstituted Fluorene Derivatives Using MoV Reagents
Franzmann, Peter,Trosien, Simon,Schubert, Moritz,Waldvogel, Siegfried R.
supporting information, p. 1182 - 1185 (2016/03/15)
Oxidative coupling using molybdenum(V) reagents provides fast access to highly functionalized 9-monosubstituted fluorenes. This synthetic approach is highly modular, is high yielding, and tolerates a variety of labile moieties, e.g. amides or iodo groups. The established protocol leads to promising precursors for pharmacologically important analogues of melatonin.
2 - (2 - PHENYLETHENYL) - 1, 3 -BENZOTHIAZINE DERIVATIVES USEFUL FOR THE TREATMENT CANCER
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Page/Page column 43, (2012/07/14)
of formula 4 The present invention provides compounds of formula (1) acting as protein kinase (PK) and receptor kinase (RK) signaling modulators. The invention further provides methods of their preparation, pharmaceutical compositions including such compo
