1565829-16-4Relevant academic research and scientific papers
Development of the direct Suzuki-Miyaura cross-coupling of primary B-alkyl MIDA-boronates and aryl bromides
St. Denis, Jeffrey D.,Scully, Conor C. G.,Lee, C. Frank,Yudin, Andrei K.
, p. 1338 - 1341 (2014)
The development of a palladium-catalyzed sp3-sp2 Suzuki-Miyaura cross-coupling of B-alkyl-N-methyliminodiacetyl (B-alkyl MIDA) boronates and (hetero)aryl bromides is reported. This transformation is tolerant of a variety of functional groups (F, NO2, CN, Cl, COCH3, and CHO). B-Alkyl MIDA boronates allow an efficient cross-coupling reaction directed toward the synthesis of unsymmetrical methylene diaryls as well as alkylated arenes in good to excellent yields.
