1565863-74-2Relevant academic research and scientific papers
Efficient Pd-Catalyzed C—H Oxidative Bromination of Arenes with Dimethyl Sulfoxide and Hydrobromic Acid?
Yuan, Yizhi,Liang, Yujie,Shi, Shihui,Liang, Yu-Feng,Jiao, Ning
supporting information, p. 1245 - 1251 (2020/07/27)
We have developed an efficient Pd-catalyzed directed C—H bromination protocol, in which dimethyl sulfoxide (DMSO) is employed as oxidant with hydrobromic acid aqueous solution (HBr(aq)) as bromide source. The DMSO/HBr(aq) system, which is novelly and efficiently utilized in transition-metal catalyzed C—H activation, illustrates its practicability by the operational simplicity, inexpensive and readily available starting materials, and high bromide-atom economy.
Cu-mediated direct aryl C - H halogenation: A strategy to control mono- and di-selectivity
Du, Zhi-Jun,Gao, Lian-Xun,Lin, Ying-Jie,Han, Fu-She
, p. 123 - 126 (2014/01/23)
A protocol for the copper-mediated direct aryl C - H halogenation is presented. Highly selective mono- and di-halogenations are achieved by using acyl hypohalites, generated in situ from the readily available carboxylic acid and N-halosuccinimides (NXS; X=Br and Cl) as powerful halogenating reagents. The correct choice of carboxylic acid additives and solvents is essential for both high yield and selectivity. Consequently, the use of inexpensive Cu catalyst and the new strategy for the in situ generation of acyl hypohalite halogenating reagents from the readily affordable and easily-to-handle carboxylic acid and NXS (X=Br and Cl) offers advantages for practical application. Copyright
