1565871-29-5Relevant academic research and scientific papers
Iron-catalyzed vinylogous aldol condensation of biginelli products and its application toward pyrido[4,3- d ]pyrimidinones
Zhang, Lianqiang,Zhang, Zhiguo,Liu, Qingfeng,Liu, Tongxin,Zhang, Guisheng
, p. 2281 - 2288 (2014)
A novel iron-catalyzed vinylogous aldol condensation of Biginelli products with aryl aldehydes has been developed for the syntheses of potential bioactive (E)-6-arylvinyl-dihydropyrimidin-2(1H)-ones. These materials are valuable synthetic precursors to drug-like pyrido[4,3-d]pyrimidine derivatives. The amide group at the 5-position of the dihydropyrimidin-2(1H)-ones played an important role in the vinylogous aldol condensation reaction.
