1566-41-2

Basic information

• Product Name: 1-(4-hydroxyphenyl)urea
• Synonyms: urea, N-(4-hydroxyphenyl)-
• CAS NO: 1566-41-2
• Molecular Formula: C₇H₈N₂O₂
• Molecular Weight: 152.1506
• Mol File: 1566-41-2.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 316.1°C at 760 mmHg
• Flash Point: 145°C
• Density: 1.407g/cm³
• Vapor Pressure: 0.000226mmHg at 25°C
• Refractive Index: 1.689
• CAS DataBase Reference: 1-(4-hydroxyphenyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-hydroxyphenyl)urea(1566-41-2)
• EPA Substance Registry System: 1-(4-hydroxyphenyl)urea(1566-41-2)

Safety Data

• Hazardous Substances Data: 1566-41-2(Hazardous Substances Data)

Usage

General Description

1-(4-hydroxyphenyl)urea is a chemical compound with the molecular formula C7H8N2O2. It is an organic compound containing a urea group linked to a hydroxyphenyl group. 1-(4-hydroxyphenyl)urea is a white crystalline solid that is used in the synthesis of pharmaceuticals and agrochemicals. It has been studied for its potential anti-cancer and anti-inflammatory properties. 1-(4-hydroxyphenyl)urea may also be used in the production of polyurethane and epoxy resins. Additionally, 1-(4-hydroxyphenyl)urea has been investigated for its potential use in the development of organic light-emitting diodes (OLEDs) due to its unique combination of fluorescent and phosphorescent properties.

Upstream product

• 123-30-8 4-amino-phenol 
• 1118-02-1 trimethylsilyl isocyanate 
• 106-48-9 4-chloro-phenol 
• 917-61-3 sodium isocyanate 
• 42003-65-6 4-<(trimethylsilyl)oxy>phenyl isocyanate 
• 100238-66-2 (4-Trimethylsilanyloxy-phenyl)-urea 
• 140678-07-5 p-nitrophenyl 4-ureidophenylcarbonate 
• 140678-06-4 phenyl 4-ureidophenylcarbonate 
• 590-28-3 potassium cyanate 
• 140678-05-3 ethyl 4-ureidophenylcarbonate 
• 556-89-8 nitrourea 

Downstream Products

• 59746-11-1 (4-acetoxy-phenyl)-urea 
• 140678-06-4 phenyl 4-ureidophenylcarbonate 
• 64833-51-8 ibuprofen p-hydroxyphenylurea ester 
• 1129683-83-5 4-[ ({[4-chloro-3-(trifluoromethyl)phenyl]amino}carbonyl)amino]phenol 
• 2298-29-5 N-(4-hydroxyphenyl)-N'-phenylurea 
• 501646-39-5 1-(tert-butyl)-3-(4-hydroxyphenyl)urea 
• 23159-73-1 N-Isopropyl-N'-(4-hydroxyphenyl)harnstoff 
• 1455483-00-7 1-(4-(prop-2-ynyloxy)phenyl)urea 
• 1455482-97-9 C₃₂H₃₆N₈O₆S 
• 1455482-96-8 C₃₂H₃₅BrN₈O₆S 
• 1455483-02-9 5-benzyl-5-bromo-1-(4-(prop-2-ynyloxy)phenyl)pyrimidine-2,4,6-trione 
• 1455483-01-8 5-benzyl-1-(4-(prop-2-ynyloxy)phenyl)pyrimidine-2,4,6-trione 
• 101721-39-5 [4-(2-hydroxy-3-phthalimido-propoxy)-phenyl]-urea 
• 109161-46-8 [4-(2-hydroxy-3-succinimido-propoxy)-phenyl]-urea 

Relevant articles and documents

Activated sterically strained C=N bond in N-substituted p-quinone mono- and diimines: XV. Synthesis, structure, and reactions with alcohols of N-carbamoyl-1,4-benzoquinone imines

The reaction of 4-aminophenols with N-nitrourea or with sodium cyanate in acetic acid gave the corresponding 4-ureidophenols which were oxidized to N-carbamoyl-1,4-benzoquinone imines, substituted N-(4-oxocyclohexa-2,5-dien-1-ylidene)ureas. N-(2,6-Dimethy

A practically simple, catalyst free and scalable synthesis of: N -substituted ureas in water

A practically simple, mild and efficient method is developed for the synthesis of N-substituted ureas by nucleophilic addition of amines to potassium isocyanate in water without organic co-solvent. Using this methodology, a variety of N-substituted ureas (mono-, di- and cyclic-) were synthesized in good to excellent yields with high chemical purity by applying simple filtration or routine extraction procedures avoiding silica gel purification. The developed methodology was also found to be suitable for gram scale synthesis of molecules having commercial application in large volumes. The identified reaction conditions were found to promote a unique substrate selectivity from a mixture of two amines.

Process for the Preparation of a RAF Kinase Inhibitor and Intermediates for Use in the Process

There is provided a process for preparing sorafenib or a salt thereof comprising the use of a compound of formula (A) wherein R′ is selected from the group consisting of hydrogen, —C(O)OA, —C(O)CX3, —C(O)NH2, —C(O)—NHOH or There is also provided intermediate compounds of general formula (A), N-methyl-4-(4-ureidophenoxy)picolinamide, 4-(2-(methylcarbamoyl)pyridin-4-yloxy)phenylcarbamate derivative and N-methyl-4-(4-(2,2,2-trihaloacetamido)phenoxy)picolinamide, processes for their preparation and their use in the preparation of sorafenib.