156619-66-8Relevant articles and documents
Vermiculin derivatives. Part 1: Synthesis of vermiculin derivatives
Proksa,Uhrin,Adamcova,Muckova,Fuska
, p. 738 - 740 (2007/10/02)
Hydrogenation of the macrodiolide antibiotic vermiculin (1) over Adams catalyst afforded [8S,16S]-8,16-bis (2'-oxopropyl)-1,9-dioxacyclohexadeca-2,5,10,13-tetrone (2). [8S,16S]-8,16-bis (2'-oxopropyl)-13-hydroxy-1,9-dioxacyclohexadeca-2,5,10-trione (3), [8S,16S]-8,16-bis(2'oxopropyl)-1,9-dioxacyclohexadeca-2,5,10-trione (4) together with [7S]-4,9-dioxo-7-(4',9'-dioxodecanoyloxy)decanoic acid (5). Hydrogenation of diolide 1 over Pd-C gave tetrahydrovermiculin (2) only. The prepared compounds showed lower antibacterial and cytotoxic activities than vermiculin (1).