156620-46-1

Basic information

• Product Name: amythiamicin D
• Synonyms: amythiamicin D
• CAS NO: 156620-46-1
• Molecular Formula: C43H42N12O7S6
• Molecular Weight: 1031.28
• Mol File: 156620-46-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 311-312 °C
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.378g/cm³
• Refractive Index: 1.617
• PKA: 11.10±0.70(Predicted)
• CAS DataBase Reference: amythiamicin D(CAS DataBase Reference)
• NIST Chemistry Reference: amythiamicin D(156620-46-1)
• EPA Substance Registry System: amythiamicin D(156620-46-1)

Safety Data

• Hazardous Substances Data: 156620-46-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C43H42N12O7S6/c1-17(2)30-41-51-26(15-67-41)39-48-23(12-64-39)33-20(8-9-21(46-33)38-52-27(16-65-38)43(61)62-7)37-49-25(14-63-37)35(59)47-22(10-28(56)44-6)40-55-32(19(5)68-40)36(60)54-31(18(3)4)42-50-24(13-66-42)34(58)45-11-29(57)53-30/h8-9,12-18,22,30-31H,10-11H2,1-7H3,(H,44,56)(H,45,58)(H,47,59)(H,53,57)(H,54,60)

Upstream product

• 220717-59-9 2-<(S)-1-amino-2-methylpropyl>-4-ethoxycarbonylthiazole 
• 1262975-69-8 C₃₈H₃₈BrN₁₁O₅S₅ 
• 1262975-64-3 (S)-N-[1-(4-bromo-2,4'-bithiazolyl-2'-yl)-2-methylpropyl]-N'-(9H-fluoren-9-ylmethyloxycarbonyl)-2-(amino)acetamide 
• 1262975-67-6 2-{(S)-1-[(2-{(S)-1-[(2-(2,6-dibromopyridin-3-yl)thiazol-4-ylcarbonyl)amino]-2-methylcarbamoyl-ethyl}-5-methylthiazol-4-ylcarbonyl)amino]-2-methylpropyl}thiazole-4-carboxylic acid 
• 1262975-62-1 (S)-N-[1-(4-bromothiazol-2-yl)-2-methylpropyl]-N'-(9H-fluoren-9-ylmethyloxycarbonyl)-2-(amino)acetamide 
• 1262975-61-0 (S)-1-(4-bromothiazol-2-yl)-2-methylpropane-1-amine hydrochloride 
• 1262975-60-9 (S)-N-[(S)-1-(4-bromothiazol-2-yl)-2-methylpropyl]-2-methylpropane-2-sulfinamide 
• 1262975-59-6 ethyl 2-{(S)-1-[(2-{(S)-1-[(2-(2,6-dibromopyridin-3-yl)thiazol-4-ylcarbonyl)amino]-2-methylcarbamoyl-ethyl}-5-methylthiazol-4-ylcarbonyl)amino]-2-methylpropyl}thiazole-4-carboxylate 
• 1262975-58-5 ethyl 2-{(1S)-1-[(2-{(1S)-1-[(2-iodothiazol-4-ylcarbonyl)amino]-2-methylcarbamoylethyl}-5-methylthiazol-4-ylcarbonyl)amino]-2-methylpropyl}thiazole-4-carboxylate 
• 39856-57-0 2,6-dibromo-3-aminopyridine 
• 1032582-80-1 2,6-dibromo-3-iodopyridine 
• 462-08-8 pyridin-3-ylamine 
• 706785-57-1 (S)-ethyl 2'-(1-tert-butoxycarbonylamino-2-methylpropyl)-[2,4']-bithiazoyl-4-carboximidate 
• 706785-56-0 (S)-2'-(1-tert-butoxycarbonylamino-2-methylpropyl)-[2,4']-bithiazolyl-4-carboxamide 

Relevant articles and documents

Novel antibiotics, amythiamicins - III. Structure elucidations of amythiamicins A, B and C

The structures of novel antimicrobial antibiotics, amythiamicins A, B and C, were elucidated by chemical degradations and NMR spectral analyses. The main frame from C-1 to C-41 of these antibiotics was the same as that of amythiamicin D. Amino acid autoanalyses of amythiamicins A, B and C showed that these have another one mole of serine and proline in comparison with amythiamicin D. Stereochemistries of both amino acids were determined to be L by chiral HPLC. These seryl-prolyl residues in amythiamicins A, B and C are attached at C-41 through an oxazoline ring, amide and ester bond, respectively.

Total synthesis of the thiopeptide antibiotic amythiamicin D

The thiopeptide (or thiostrepton) antibiotics are a class of sulfur containing highly modified cyclic peptides with interesting biological properties, including reported activity against MRSA and malaria. Described herein is the total synthesis of the thi