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Amythiamicin B is a naturally occurring antibiotic belonging to the thiopeptide class, which is produced by certain strains of Streptomyces bacteria. It exhibits potent antimicrobial activity against a broad spectrum of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant enterococci (VRE). Amythiamicin B works by inhibiting protein synthesis in bacteria, specifically targeting the elongation factor EF-Tu, which is essential for the translation process. This unique mechanism of action makes it a potential candidate for the development of new antibiotics to combat antibiotic-resistant infections. However, its therapeutic potential is limited due to its poor solubility and stability in physiological conditions, which has led to ongoing research efforts to improve its pharmacological properties and explore its potential as a lead compound for the development of novel antibacterial agents.

156620-48-3

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156620-48-3 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 156620-48-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,5,6,6,2 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 156620-48:
(8*1)+(7*5)+(6*6)+(5*6)+(4*2)+(3*0)+(2*4)+(1*8)=133
133 % 10 = 3
So 156620-48-3 is a valid CAS Registry Number.
InChI:InChI=1/C50H53N15O9S6/c1-20(2)35-48-61-31(19-79-48)46-57-27(15-76-46)38-23(9-10-24(54-38)45-59-30(18-77-45)42(72)56-26(14-66)50(74)65-11-7-8-32(65)39(51)69)44-58-29(17-75-44)41(71)55-25(12-33(67)52-6)47-64-37(22(5)80-47)43(73)63-36(21(3)4)49-60-28(16-78-49)40(70)53-13-34(68)62-35/h9-10,15-21,25-26,32,35-36,66H,7-8,11-14H2,1-6H3,(H2,51,69)(H,52,67)(H,53,70)(H,55,71)(H,56,72)(H,62,68)(H,63,73)

156620-48-3SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 14, 2017

Revision Date: Aug 14, 2017

1.Identification

1.1 GHS Product identifier

Product name Amythiamicin B

1.2 Other means of identification

Product number -
Other names L-Prolinamide,N-((2-(10,11,17,18,23,24,25,26,27,28-decahydro-14-methyl-11-(2-(methylamino)-2-oxoethyl)-18,28-bis(1-methylethyl)-9,16,23,26-tetraoxo-9H,16H-8,5:15,12:22,19:32,29:36,33-pentanitrilo-5H,29H,33H-pyrido(3,2-a1)(1,11,18,25,31,4,7,14,21)pentathiatetraazacyclotetratriacontin-2-yl)-4-thiazolyl)carbonyl)-L-seryl

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:156620-48-3 SDS

156620-48-3Upstream product

156620-48-3Downstream Products

156620-48-3Relevant academic research and scientific papers

Total syntheses of amythiamicins A, B and C

Nicolaou,Dethe, Dattatraya H.,Chen, David Y.-K.

, p. 2632 - 2634 (2008)

Total syntheses of the thiopeptide antibiotics amythiamicins A, B and C are reported. The Royal Society of Chemistry.

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