156624-78-1

Basic information

• Product Name: (S)-2H-ISOINDOLE-2-ACETIC ACID, 1,3-DIHYDRO-ALPHA-[(4-METHOXYPHENYL)METHYL]-1,3-DIOXO-, METHYL ESTER
• Synonyms: (S)-2H-ISOINDOLE-2-ACETIC ACID, 1,3-DIHYDRO-ALPHA-[(4-METHOXYPHENYL)METHYL]-1,3-DIOXO-, METHYL ESTER
• CAS NO: 156624-78-1
• Molecular Formula: C19H17NO5
• Molecular Weight: 339.34
• Mol File: 156624-78-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 502.6±45.0 °C(Predicted)
• Appearance: /
• Density: 1.308±0.06 g/cm3(Predicted)
• PKA: -2.51±0.20(Predicted)
• CAS DataBase Reference: (S)-2H-ISOINDOLE-2-ACETIC ACID, 1,3-DIHYDRO-ALPHA-[(4-METHOXYPHENYL)METHYL]-1,3-DIOXO-, METHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2H-ISOINDOLE-2-ACETIC ACID, 1,3-DIHYDRO-ALPHA-[(4-METHOXYPHENYL)METHYL]-1,3-DIOXO-, METHYL ESTER(156624-78-1)
• EPA Substance Registry System: (S)-2H-ISOINDOLE-2-ACETIC ACID, 1,3-DIHYDRO-ALPHA-[(4-METHOXYPHENYL)METHYL]-1,3-DIOXO-, METHYL ESTER(156624-78-1)

Safety Data

• Hazardous Substances Data: 156624-78-1(Hazardous Substances Data)

Usage

General Description

(S)-2H-ISOINDOLE-2-ACETIC ACID, 1,3-DIHYDRO-ALPHA-[(4-METHOXYPHENYL)METHYL]-1,3-DIOXO-, METHYL ESTER is a chemical compound that consists of an isoindole-2-acetic acid core with a 1,3-dihydro-alpha-[(4-methoxyphenyl)methyl]-1,3-dioxo side chain and a methyl ester functional group. (S)-2H-ISOINDOLE-2-ACETIC ACID, 1,3-DIHYDRO-ALPHA-[(4-METHOXYPHENYL)METHYL]-1,3-DIOXO-, METHYL ESTER is a derivative of isoindole-2-acetic acid, which is a heterocyclic organic compound. The presence of the methoxyphenyl group suggests potential pharmacological properties, as methoxy-substituted compounds are known for their diverse biological activities. The methyl ester functionality also indicates potential for use in medicinal chemistry and drug development. Overall, this compound's unique structure and functional groups make it a potential candidate for further investigation in the fields of pharmaceuticals and chemical research.

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Relevant articles and documents

Chiral diene-promoted room temperature conjugate arylation: Highly enantioselective synthesis of substituted chiral phenylalanine derivatives and α,α-di(arylmethyl)acetates

A highly enantiocontrolled room temperature rhodium-catalyzed conjugate arylation process was developed. The reaction proceeds through 1,4-addition of α-substituted acrylates followed by enantioselective protonation using a C1-symmetric chiral bicyclo[2,2,2] diene as the ligand and water as the proton source. This exceptionally simple protocol provides a reliable and practical access to structurally important phenylalanine derivatives and α,α-di(arylmethyl)acetates in high yields (up to 99%) with good to excellent ee values (up to 99%).

Cation Radical Accelerated Nucleophilic Aromatic Substitution via Organic Photoredox Catalysis

Nucleophilic aromatic substitution (SNAr) is a direct method for arene functionalization; however, it can be hampered by low reactivity of arene substrates and their availability. Herein we describe a cation radical-accelerated nucleophilic aromatic substitution using methoxy- and benzyloxy-groups as nucleofuges. In particular, lignin-derived aromatics containing guaiacol and veratrole motifs were competent substrates for functionalization. We also demonstrate an example of site-selective substitutive oxygenation with trifluoroethanol to afford the desired trifluoromethylaryl ether.

Catalytic asymmetric protonation of α-amino acid-derived ketene disilyl acetals using P -Spiro diaminodioxaphosphonium barfates as chiral proton

Chiral diaminodioxaphosphonium salts have been developed and their unique abilities as a chiral proton have been revealed through the establishment of a highly enantioselective protonation of α-amino acid-derived ketene disilyl acetals.