156647-96-0

Basic information

• Product Name: 4-HYDROXY-6-METHYLPYRIMIDINE
• Synonyms: AKOS BC-0740;6-METHYL-4(3H)-PYRIMIDINONE;4-Pyrimidinol, 6-methyl- (9CI);2-Ethyl-6-methyl-3-pyridinol succinate;Mexidol Emicidine
• CAS NO: 156647-96-0
• Molecular Formula: C₅H₆N₂O
• Molecular Weight: 110.11
• EINECS: 222-543-4
• Product Categories: PYRIMIDINE
• Mol File: 156647-96-0.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 242.1℃
• Flash Point: 100.2℃
• Appearance: /
• Density: 1.215
• Vapor Pressure: 0.496mmHg at 25°C
• Refractive Index: 1.576
• PKA: 9.11±0.10(Predicted)
• CAS DataBase Reference: 4-HYDROXY-6-METHYLPYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-HYDROXY-6-METHYLPYRIMIDINE(156647-96-0)
• EPA Substance Registry System: 4-HYDROXY-6-METHYLPYRIMIDINE(156647-96-0)

Safety Data

• Hazardous Substances Data: 156647-96-0(Hazardous Substances Data)

Usage

General Description

4-HYDROXY-6-METHYLPYRIMIDINE is a chemical compound with the molecular formula C5H6N2O. It is a pyrimidine derivative with a hydroxyl group and a methyl group attached to the 4th and 6th carbon atoms, respectively. 4-HYDROXY-6-METHYLPYRIMIDINE can be found in nature and is an intermediate in the biosynthesis of certain nucleotides and coenzymes. It is also used in organic synthesis as a starting material for the production of various pharmaceuticals and agricultural chemicals. 4-HYDROXY-6-METHYLPYRIMIDINE is considered to be an important building block in the field of medicinal chemistry and drug discovery.

InChI:InChI=1/C5H6N2O/c1-4-2-5(8)7-3-6-4/h2-3H,1H3,(H,6,7,8)

Upstream product

• 3524-87-6 6-methyl-3H-pyrimidin-4-one 
• 3473-63-0 formamidine acetic acid 
• 105-45-3 acetoacetic acid methyl ester 
• 6328-58-1 4-Hydroxy-6-methyl-2-methylthiopyrimidine 
• 21731-17-9 methyl 3-aminocrotonate 
• 71-36-3 butan-1-ol 
• 56-04-2 6-methyl-2-thiouracil 

Downstream Products

• 3438-52-6 5-bromo-6-methylpyrimidin-4-ol 
• 1436405-35-4 N-((5-((4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-6-methylpyrimidin-5-yl)ethynyl)furan-2-yl)methyl)-2-(methylsulfonyl)ethanamine 
• 1436405-34-3 4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-5-ethynyl-6-methylpyrimidine 
• 1436405-33-2 4-(3-chloro-4-(pyridin-2-ylmethoxy)phenoxy)-5-iodo-6-methylpyrimidine 
• 1436405-31-0 N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-5-ethynyl-6-methylpyrimidin-4-amine 
• 912353-90-3 N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-methyl-5-((5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)ethynyl)pyrimidin-4-amine 
• 1436405-30-9 N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-methyl-5-(2-(5-(((2-(methylsulfonyl)ethyl)amino)methyl)furan-2-yl)vinyl)pyrimidin-4-amine 
• 1436405-28-5 N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-6-methyl-5-vinylpyrimidin-4-amine 
• 912354-47-3 N-(3-chloro-4-((3-fluorobenzyl)oxy)phenyl)-5-iodo-6-methylpyrimidin-4-amine 
• 1436405-29-6 N-(3-(-2-(4-((3-chloro-4-((3-fluorobenzyl)oxy)phenyl)amino)-6-methylpyrimidin-5-yl)vinyl)phenyl)-4-(dimethylamino)but-2-enamide 
• 83410-15-5 4-chloro-5-iodo-6-methyl-pyrimidine 
• 7752-74-1 4-hydroxy-5-iodo-6-methylpyrimidine 
• 7752-74-1 5-iodo-6-methyl-3H-pyrimidin-4-one 

Relevant articles and documents

-

-

5-ALKYNYL-PYRIMIDINES

The present invention encompasses compounds of general formula (1) wherein R1 to R4 R3 are defined as in claim 1, which are suitable for the treatment of diseases characterised by excessive or abnormal cell proliferation, and the use thereof for preparing a medicament having the above-mentioned properties.

A method for the reductive scission of heterocyclic thioethers

A mild, chemoselective, and generally high-yielding method for the reductive scission of heterocyclic thioethers is described. Suitable heterocycles have a thioether substituent at the 2-position relative to a ring heteroatom. The convenient and straightforward method is demonstrated with reactants which are not compatible with the standard Raney nickel conditions such as sulfides, sulfones, and thiophenes. In addition, benzyl esters, benzyl amides, and benzyl carbamates are tolerated by the reductive reaction conditions.