1566513-08-3Relevant academic research and scientific papers
Fluoro-substituted phenylazocarboxamides: Dopaminergic behavior and N-arylating properties for irreversible binding
Bartuschat, Amelie L.,Schellhorn, Tamara,Hübner, Harald,Gmeiner, Peter,Heinrich, Markus R.
, p. 3938 - 3947 (2015)
Phenylazocarboxamides can serve as bioisosteres for cinnamides, which are widely occurring substructures in medicinal chemistry. Starting from our lead compound 2, the introduction of additional fluoro substituents and the exchange of the methoxyphenylpip
Oxidative radical arylation of anilines with arylhydrazines and dioxygen from air
Hofmann, Josefa,Jasch, Hannelore,Heinrich, Markus R.
, p. 2314 - 2320 (2014/04/03)
Substituted 2-aminobiphenyls have been prepared from arylhydrazine hydrochlorides and anilines in biphasic radical arylation reactions with dioxygen from air as a most simple and readily available oxidant. Under optimized conditions, the free amino functionality of the aniline leads to high ortho:meta regioselectivities, now even for anilines bearing a donor substituent in the para position. Finally, the mild and metal-free new access to aminobiphenyls was shown to be applicable on a gram scale.
