1566591-53-4

Basic information

• Product Name: N-(4-chlorophenyl)-4-methoxypyridin-2-amine
• Synonyms: N-(4-chlorophenyl)-4-methoxypyridin-2-amine
• CAS NO: 1566591-53-4
• Molecular Weight: 234.685
• Mol File: 1566591-53-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: N-(4-chlorophenyl)-4-methoxypyridin-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorophenyl)-4-methoxypyridin-2-amine(1566591-53-4)
• EPA Substance Registry System: N-(4-chlorophenyl)-4-methoxypyridin-2-amine(1566591-53-4)

Safety Data

• Hazardous Substances Data: 1566591-53-4(Hazardous Substances Data)

Upstream product

• 1122-96-9 4-methoxypyridine N-oxide 
• 1885-81-0 p-chlorophenyl isocyanide 
• 2617-79-0 N-(4-chlorophenyl)formamide 
• 89488-29-9 2-bromo-4-methoxypyridine 
• 106-47-8 4-chloro-aniline 

Relevant articles and documents

Palladium-Catalyzed Late-Stage ortho-C-H Bond Aroylation of Anilines Using 4-Methoxy-2-pyridinyl as a Removable Directing Group

A synthetic methodology for the late-stage ortho-C-H bond aroylation of anilines with aryl aldehydes led to a variety of ortho-aroylated anilines by the use of palladium(II) acetate, tert-butyl hydroperoxide, and 1,4-dioxane as the catalyst, oxidant, and solvent, respectively, is presented. An N-phenylpyridin-2-amine palladacycle was isolated and characterized by X-ray crystallography. Controlled experiments, radical trapping experiments, and the experiments of the kinetic isotope effect were undertaken to support the proposed reaction mechanism. Syntheses of 2-aminobenzophenone and 9(10H)-acridanone based on the developed methodology were successfully demonstrated.