1566598-74-0

Basic information

• Product Name: ethyl 1,5-diphenyl-4-o-tolyl-1H-pyrazole-3-carboxylate
• CAS NO: 1566598-74-0
• Molecular Weight: 382.462
• Mol File: 1566598-74-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 1,5-diphenyl-4-o-tolyl-1H-pyrazole-3-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 1,5-diphenyl-4-o-tolyl-1H-pyrazole-3-carboxylate(1566598-74-0)
• EPA Substance Registry System: ethyl 1,5-diphenyl-4-o-tolyl-1H-pyrazole-3-carboxylate(1566598-74-0)

Safety Data

• Hazardous Substances Data: 1566598-74-0(Hazardous Substances Data)

Upstream product

• 5033-67-0 2-(2-methylphenyl)-1-phenyl-1-ethanone 
• 59-88-1 phenylhydrazine hydrochloride 
• 4755-77-5 Ethyl oxalyl chloride 

Relevant articles and documents

A one-pot approach to ethyl 1,4,5-triaryl-1H-pyrazole-3-carboxylates via an improved claisen condensation-knorr reaction sequence

A one-pot approach to ethyl 1,4,5-triaryl-1H-pyrazole-3-carboxylates has been developed in moderate to high yields. The tert-BuOLi-mediated Claisen condensation of 1,2-diarylethanones and ethyl oxalyl chloride efficiently provided the enolized lithium salts of ethyl 2,4-dioxo-3,4-diarylbutanoates, which in situ reacted with arylhydrazine hydrochlorides via a hydrochloric acid-promoted Knorr reaction to produce the exquisite triarylpyrazole-3- carboxylates. The procedure promises a convenient access to this highly crowded framework for drug discovery. Copyright