156691-84-8

Basic information

• Product Name: 5-[(1E)-2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl]thiophene-3-carboxylic acid
• Synonyms: 3-thiophenecarboxylic acid, 5-[(1E)-2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthalenyl)-1-propen-1-yl]-
• CAS NO: 156691-84-8
• Molecular Formula: C₂₃H₂₈O₂S
• Molecular Weight: 368.5322
• Mol File: 156691-84-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 500°C at 760 mmHg
• Flash Point: 256.2°C
• Density: 1.101g/cm³
• Vapor Pressure: 8.15E-11mmHg at 25°C
• Refractive Index: 1.587
• CAS DataBase Reference: 5-[(1E)-2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl]thiophene-3-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(1E)-2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl]thiophene-3-carboxylic acid(156691-84-8)
• EPA Substance Registry System: 5-[(1E)-2-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)prop-1-en-1-yl]thiophene-3-carboxylic acid(156691-84-8)

Safety Data

• Hazardous Substances Data: 156691-84-8(Hazardous Substances Data)

Upstream product

• 156691-83-7 (E)-4-bromo-2-<2-(5,6,7,8-tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl)propen-1-yl>thiophene 
• 18791-75-8 4-Bromothiophen-2-aldehyde 
• 124-38-9 carbon dioxide 

Relevant articles and documents

Assay for identification of compounds that promote melanin production and retinoid-like compounds identified by said assay

An in vitro assay for selecting compounds that alter pigmentation of skin is provided. Also, a novel class of pro-pigmentatory compounds is provided which comprise substituted aromatic or heterocyclic carboxylic acids, or derivatives thereof, or pharmaceutically acceptable salts, which do not contain a pheno, naphthol, thiophenol, or a thionaphthol function in free or protected form. In a preferred embodiment, thess compounds will display activity for RXRs. These compounds may be used for altering pigmentation of human skin and/or hair in cosmetic or dermatological compositions, and for the treatment of disorders and disease conditions that affect skin or hair pigmentation.

SYNERGISTIC THERAPEUTIC COMPOSITIONS COMPRISING AT LEAST ONE LIGAND SPECIFIC FOR RXRS AT LEAST ONE LIGAND SPECIFIC FOR RAR-ALPHA

Pharmaceutical/dermatological compositions comprising (a) at least one first ligand displaying selective activity for the RXR receptors and (b) at least one second ligand displaying selective activity for the RAR-. alpha. receptor, are useful for modulating the proliferation and/or differentiation of HL-60 type cells, in particular for the systemic treatment of acute promyelocytic leukemia.

Method of treatment with compounds having retinoid-like activity and reduced skin toxicity and lacking teratogenic effects

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