156706-51-3

Basic information

• Product Name: Carbamic acid, [(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]-, 1,1-
• Synonyms: Carbamic acid, [(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]-, 1,1-
• CAS NO: 156706-51-3
• Molecular Formula: C₈H₁₆N₂O₄
• Molecular Weight: 204.22364
• Product Categories: N-BOC
• Mol File: 156706-51-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Carbamic acid, [(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]-, 1,1-(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]-, 1,1-(156706-51-3)
• EPA Substance Registry System: Carbamic acid, [(1S)-2-(hydroxyamino)-1-methyl-2-oxoethyl]-, 1,1-(156706-51-3)

Safety Data

• Hazardous Substances Data: 156706-51-3(Hazardous Substances Data)

Upstream product

• 15761-38-3 L-N-Boc-Ala 
• 24424-99-5 di-tert-butyl dicarbonate 
• 631914-55-1 Boc-L-Ala-Cl 
• 39982-01-9 tert-Butoxycarbonylpivalat 
• 28875-17-4 (S)-N-(tert-butoxycarbonyl)alanine methyl ester 

Downstream Products

• 160057-21-6 1(R)-1-<(tert-Butyldiphenylsilyl)oxy>-4(S)-cyclopent-2-ene 
• 160057-23-8 {(S)-1-[(1S,2R,3R,4R)-4-(tert-Butyl-diphenyl-silanyloxy)-2,3-dihydroxy-cyclopentylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 
• 160057-25-0 {(S)-1-[(3aR,4S,6R,6aR)-6-(tert-Butyl-diphenyl-silanyloxy)-2,2-dimethyl-tetrahydro-cyclopenta[1,3]dioxol-4-ylcarbamoyl]-ethyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Organocatalytic Multicomponent Synthesis of α/β-Dipeptide Derivatives

A straightforward multicomponent Knoevenagel-aza-Michael-cyclocondensation reaction involving readily available hydroxamic acid-derived from naturally occurring α-amino acids allows a diversity-oriented synthesis of novel isoxazolidin-5-ones possessing an N-protected α-amino acid pendant with good to high diastereoselectivities thanks to a match effect with a chiral organocatalyst. These diversely substituted heterocycles, easily isolated as a single diastereoisomer, proved to be versatile platforms for the formation of an array of α/β-dipeptide fragments.

Simple one-flask method for the preparation of hydroxamic acids

(Matrix presented) A one-step conversion of carboxylic acids to hydroxamic acids under very mild conditions is described. This simple and efficient method has been applied for the synthesis of enantiopure hydroxamate of α-amino acids and peptides.

Effective synthesis of enantiopure hydroxamates by displacement of resin-bound esters with hydroxylamine

Enantiopure hydroxamic acids have been synthesized by nucleophilic displacement of carboxylates linked to oxime resin using hydroxylamine in a MeOH:CHCl3 solution.

CHEMOTHERAPEUTIC OLIGOPEPTIDE MIMETICS

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The synthesis of Nα-protected amino hydroxamic acids from Nα-protected amino acids employing versatile chlorinating agent CPI-Cl

Racemization free synthesis of Nα-protected amino hydroxamic acids from Nα-protected amino acids employing the versatile chlorinating reagent CPI-Cl has been described in one-pot. The present protocol has shown compability towards urethane protecting groups like Boc, Cbz and Fmoc, and side chain protections of amino acids showed complete tolerance.

Efficient continuous flow synthesis of hydroxamic acids and suberoylanilide hydroxamic acid preparation

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COMPOSITIONS HAVING ANTIMYCROBIAL ACTIVITY INCLUDING A HYDROXAMATE OR A HYDROXAMATE AND A HYDROXYLAMINE

Antimycorbacterial compositions are disclosed comprising at least one hydroxamate or at least one hydroxamate and at least one hydroxylamine. The preferred ratio of hydroxamate to hydroxylamines is about 100:1 to about 1:1. A method for inhibiting mycobacterial growth is also disclosed comprising the step of administering the compositions of this invention to an animal including a human.