156726-71-5Relevant academic research and scientific papers
Tris(trimethylsilyl)[2H]silane-triethylborane system producing the highly diastereoselective deuteration (> 99:1) of 2'-bromo-2'-deoxy- and 2'-O-phenoxythiocarbonylribonucleosides at 0°C
Kawashima, Etsuko,Uchida, Seishiro,Miyahara, Masayoshi,Ishido, Yoshiharu
, p. 7369 - 7372 (2007/10/03)
Reductive protylation and deuteration reactions using (Me3Si)3SiH- and (Me3Si)3Si2H-Et3B systems were investigated in view of the differences in bond energy and bond length between the Si-H of (Me3Si)3SiH and the Sn-H of Bu3SnH. Higher diastereoselectivity was obtained in comparison with the reactions using the Bu3SnH- and Bu3Sn2H-Et3B systems; the (Me3Si)3SiH system gave remarkable diastereoselectivity of 98.7% at 0°C, whereas the other system required temperatures below -70°C.
