156731-34-9

Usage

Uses

Used in Peptide Synthesis:
1-N-BOC-AMINO-2-CYCLOPENTENE is used as a building block in peptide synthesis for the creation of complex peptide structures. Its N-BOC protection allows for selective reactions and controlled synthesis, which is crucial in the development of new biologically active molecules and pharmaceuticals.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, 1-N-BOC-AMINO-2-CYCLOPENTENE is used as a component in the synthesis of potential drug candidates. Its role in creating diverse peptide structures enables the exploration of new therapeutic agents with specific biological activities.
Used in Biological Research:
1-N-BOC-AMINO-2-CYCLOPENTENE is utilized in biological research as a tool for studying protein structure and function. Its incorporation into peptides can help researchers understand the interactions between proteins and other biomolecules, contributing to a deeper understanding of biological processes.

Upstream product

• 100727-30-8 2-(cyclopent-2-en-1-yl)isoindoline-1,3-dione 
• 24424-99-5 di-tert-butyl dicarbonate 
• 142-29-0 cyclopentene 
• 95514-62-8 (E)-ethyl hepta-2,6-dienoate 
• 62019-06-1 (E)-2,6-heptadien-1-ol 
• 927837-71-6 C₉H₁₂Cl₃NO 
• 81097-48-5 N-tosyl-6-azabicyclo[3.1.0]hexane 
• 153789-12-9 N-(tert-butoxycarbonyl)-6-azabicyclo<3.1.0>hexane 

Downstream Products

• 34404-28-9 N-[(1,1-dimethylethoxy)carbonyl]-D-glutamic acid 
• 657397-01-8 (2R)-(4-oxocyclopent-2-enyl)-carbamic acid tert-butyl ester 
• 189625-12-5 (+)-(1S,4R)-1-hydroxy-4-[(tert-butoxycarbonyl)amino]-2-cyclopentene 

Relevant academic research and scientific papers

PCSK9 INHIBITORS AND METHODS OF USE THEREOF

The invention relates to a novel inhibitor pharmacophore of PCSK9 and heteroaryl compounds that bind the PCSK9 protein.

PCSK9 INHIBITORS AND METHODS OF USE THEREOF

The invention relates to novel heteroaryl compounds and pharmaceutical preparations thereof. The invention further relates to methods of treating or preventing cardiovascular diseases, and methods treating sepsis or septic shock, using the novel heterocyclic compounds disclosed herein.

Asymmetric synthesis of cis-aminocyclopentenols, building blocks for medicinal chemistry

A highly efficient one-pot multistep process involving an asymmetric Pd(II)-catalyzed Overman rearrangement and a Ru(II)-catalyzed ring-closing metathesis reaction has been developed for the preparation of (R)- or (S)-aminocyclopenta-2-enes. The rapid strategy employed and the relatively mild conditions of the one-pot process allowed the multigram synthesis of the carbocycles in high enantiomeric excess (92% ee). The synthetic utility of these compounds was demonstrated by the stereoselective incorporation of hydroxyl groups, generating cis-4- and cis-5-aminocyclopenta-2-en-1-ols, important building blocks for medicinal chemistry.

On the α-lithiation-rearrangement of N-toluensulfonyl aziridines: Mechanistic and synthetic aspects

A detailed study of the rearrangement of five cycloalkene N-toluenesulfonyl (tosyl) aziridines using sec-butyllithium (with and without added ligands such as (-)-sparteine and TMEDA) has been carried out. Allylic sulfonamides were the main products from the cyclopentene and cyclohexene aziridines whereas bicyclic sulfonamides were obtained from the cycloheptene and cyclooctene aziridines. In most cases, p-toluenesulfonamide (TsNH 2) was produced as a by-product and a mechanistic explanation for its formation is forwarded. These reactions are believed to involve α-lithiation to a lithiated aziridine which can then partition through two pathways: (i) rearrangement to allylic or bicyclic sulfonamides via C-H insertion reactions or (ii) reductive alkylation to alkenes via attack by sec-butyllithium and subsequent elimination of TsNH2. In the (-)-sparteine reactions, the products were generated with 38-66% ee and the sense of asymmetric induction involved lithiation of the S-aziridine stereocentre. This is opposite to that observed with epoxides.

Asymmetric Catalysis by Vitamin B12: The Isomerization of Achiral Aziridines to Optically Active Allylic Amines

Achiral N-acylaziridines are isomerized to optically active N-acyl-allylamines in ee's of up to 95percent by catalytic amounts of cob(I)alamin in MeOH.