156744-09-1

Basic information

• Product Name: Benzaldehyde, 2,4-dipropoxy-
• Synonyms: Benzaldehyde,2,4-dipropoxy;2,4-Dipropoxy-benzaldehyde
• CAS NO: 156744-09-1
• Molecular Formula: C13H18O3
• Molecular Weight: 222.284
• Mol File: 156744-09-1.mol

Chemical Properties

• CAS DataBase Reference: Benzaldehyde, 2,4-dipropoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 2,4-dipropoxy-(156744-09-1)
• EPA Substance Registry System: Benzaldehyde, 2,4-dipropoxy-(156744-09-1)

Safety Data

• Hazardous Substances Data: 156744-09-1(Hazardous Substances Data)

Upstream product

• 106-94-5 propyl bromide 
• 95-01-2 2,4-Dihydroxybenzaldehyde 

Downstream Products

• 1256244-51-5 (Z)-5-(2,4-dipropoxybenzylidene)imidazolidine-2,4-dione 

Relevant articles and documents

Design, synthesis and in vitro and in vivo antitumour activity of 3-benzylideneindolin-2-one derivatives, a novel class of small-molecule inhibitors of the MDM2-p53 interaction

A novel class of small-molecule inhibitors of MDM2-p53 interaction with a (E)-3-benzylideneindolin-2-one scaffold was identified using an integrated virtual screening strategy that combined both pharmacophore- and structure-based approaches. The hit optimisation identified several compounds with more potent activity than the hit compound and the positive drug nutlin-3a, especially compound 1b, which exhibited both the highest binding affinity to MDM2 (K i = 0.093 μM) and the most potent antiproliferative activity against HCT116 (wild type p53) cells (GI50 = 13.42 μM). Additionally, 1b dose-dependently inhibited tumour growth in BALB/c mice bearing CT26 colon carcinoma, with no visible sign of toxicity. In summary, compound 1b represents a novel and promising lead structure for the development of anticancer drugs as MDM2-p53 interaction disruptors.