156756-47-7

Basic information

• Product Name: 5-chloro-7-methylimidazopyrimidine-2-carboxylic acid
• Synonyms: 5-chloro-7-methylimidazopyrimidine-2-carboxylic acid
• CAS NO: 156756-47-7
• Molecular Formula: C8H6ClN3O2
• Molecular Weight: 211.61
• Mol File: 156756-47-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-chloro-7-methylimidazopyrimidine-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-7-methylimidazopyrimidine-2-carboxylic acid(156756-47-7)
• EPA Substance Registry System: 5-chloro-7-methylimidazopyrimidine-2-carboxylic acid(156756-47-7)

Safety Data

• Hazardous Substances Data: 156756-47-7(Hazardous Substances Data)

Upstream product

• 5600-21-5 2-amino-6-methyl-4-chloropyrimidine 
• 134044-64-7 ethyl 5-chloro-7-methylimidazo<1,2-a>pyrimidine-2-carboxylate 

Relevant articles and documents

Research on heterocyclic compounds. XXXII. Synthesis and cyclooxygenase-independent antiinflammatory and analgesic activity of imidazopyrimidine derivatives

The synthesis of a group of imidazopyrimidine-2-carboxylic esters, acids and amides is described.The structures of the new compounds are supported by 1H- and 13C-NMR spectra.These compounds were tested in vivo for their antiinflammatory and analgesic activities as well as for their ulcerogenic action.The ester 5b, the acid 6c and the amide 7a showed antiinflammatory action in the rat paw edema (ca. 1/3 x indomethacin), while almost all compounds displayed significant analgesic activity in the acetic acid writhing test, particularly the 5-chloro-7-methyl derivatives 5a, 6a and 7a (ca 1/5 x indomethacin).All new compounds were found to be lacking in inhibitory activity on cyclooxygenase in vitro. imidazopyrimidines / antiinflammatory activity / analgesic activity / ulcerogenic activity / cyclooxygenase inhibition