Welcome to LookChem.com Sign In|Join Free

CAS

  • or

15676-16-1

Post Buying Request

15676-16-1 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

15676-16-1 Usage

Chemical Properties

Sulpiride is White Solid

Originator

Dogmatil,Delagrange,France,1969

Uses

Different sources of media describe the Uses of 15676-16-1 differently. You can refer to the following data:
1. Sulpiride is an antipsychotic drug used in the treatment of Schozophrenia and depression.
2. dopamine receptor antagonist, antipsychotic
3. Sulpiride possesses moderate neuroleptic activity along with some stimulating and antidepressant effects. It has antiemetic, moderately cataleptogenic, and antiserotonin action. It facilitates increased blood flow in the stomach. It speeds up the restorative processes in tissues. It is used for schizophrenia, depression, migraines, disturbance of behavioral functions, and stomach and duodenal ulcers.

Definition

Sulpiride is a member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.

Manufacturing Process

1-Ethyl-2-aminomethylpyrrolidine is reacted with 2-methoxy-5- sulfamoylbenzoic acid to give sulpiride.

Brand name

Dogmatyl (Laboratoires Delagrange, France).

Therapeutic Function

Tranquilizer, Digestive aid

Biological Activity

Standard D 2 -like dopamine receptor antagonist.

Biochem/physiol Actions

(±)-Sulpiride is a D2 dopamine antagonist and an effective treatment for schizophrenia when used in combination with clozapine, a relatively weak D2-dopaminergic antagonist. It is an antipsychotic agent and also exhibits neuroleptic properties but poorly penetrates the central nervous system.45,46

Clinical Use

Antipsychotic: Acute and chronic schizophrenia

Synthesis

Sulpiride, N-[(1-ethyl-2-pirrolidinylmethyl]-5-sulfamoyl-O-anizamide (6.7.2), is synthesized from 5-aminosulfosalycilic acid. Methylating this with dimethylsulfate gives 2-methoxy-5-aminosulfonylbenzoic acid (6.7.1), which is transformed into an amide using 2-aminomethyl-1-ethylpyrrolidine as amine components and carbonyl-1,1′-bisimidazole as a condensing agent [70–74].

Drug interactions

Potentially hazardous interactions with other drugs Anaesthetics: enhanced hypotensive effect. Analgesics: increased risk of convulsions with tramadol; enhanced hypotensive and sedativeeffects with opioids; increased risk of ventricular arrhythmias with methadone. Anti-arrhythmics increased risk of ventricular arrhythmias with anti-arrhythmics that prolong the QT interval, e.g. procainamide, disopyramide and amiodarone - avoid with amiodarone. Antibacterials: increased risk of ventricular arrhythmias with moxifloxacin and parenteral erythromycin - avoid with moxifloxacin. Antidepressants: possibly increased risk of ventricular arrhythmias and antimuscarinic side effects with tricyclics - avoid. Antiepileptics: antagonism (convulsive threshold lowered). Antimalarials: avoid with artemether/lumefantrine. Antipsychotics: increased risk of ventricular arrhythmias with droperidol, haloperidol and pimozide - avoid; possible increased risk of ventricular arrhythmias with risperidone. Antivirals: concentration possibly increased by ritonavir. Anxiolytics and hypnotics: increased sedative effects. Atomoxetine: increased risk of ventricular arrhythmias. Beta-blockers: enhanced hypotensive effect; increased risk of ventricular arrhythmias with sotalol. Cytotoxics: increased risk of ventricular arrhythmias with vandetanib - avoid; increased risk of ventricular arrhythmias with arsenic trioxide. Diuretics: enhanced hypotensive effect. Lithium: increased risk of extrapyramidal side effects and possibly neurotoxicity. Pentamidine: increased risk of ventricular arrhythmias.

Metabolism

Sulpiride undergoes little metabolism. 95% of a dose is excreted in the urine and faeces, mainly as unchanged drug.

Check Digit Verification of cas no

The CAS Registry Mumber 15676-16-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 1,5,6,7 and 6 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 15676-16:
(7*1)+(6*5)+(5*6)+(4*7)+(3*6)+(2*1)+(1*6)=121
121 % 10 = 1
So 15676-16-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H23N3O4S/c1-3-18-8-4-5-11(18)10-17-15(19)13-9-12(23(16,20)21)6-7-14(13)22-2/h6-7,9,11H,3-5,8,10H2,1-2H3,(H,17,19)(H2,16,20,21)/p+1/t11-/m1/s1

15676-16-1 Well-known Company Product Price

  • Brand
  • (Code)Product description
  • CAS number
  • Packaging
  • Price
  • Detail
  • TCI America

  • (S0501)  (±)-Sulpiride  >98.0%(HPLC)(T)

  • 15676-16-1

  • 5g

  • 330.00CNY

  • Detail
  • TCI America

  • (S0501)  (±)-Sulpiride  >98.0%(HPLC)(T)

  • 15676-16-1

  • 25g

  • 850.00CNY

  • Detail
  • Sigma

  • (S8010)  (±)-Sulpiride  

  • 15676-16-1

  • S8010-25G

  • 1,003.86CNY

  • Detail
  • Sigma

  • (S8010)  (±)-Sulpiride  

  • 15676-16-1

  • S8010-100G

  • 3,361.41CNY

  • Detail

15676-16-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name sulpiride

1.2 Other means of identification

Product number -
Other names Sulpiride

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15676-16-1 SDS

15676-16-1Synthetic route

1-ethyl-2-pyrrolidinemethanamine
26116-12-1

1-ethyl-2-pyrrolidinemethanamine

2-methoxy-5-sulfamoylbenzoic acid ethyl ester
33045-53-3

2-methoxy-5-sulfamoylbenzoic acid ethyl ester

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

Conditions
ConditionsYield
In glycerol at 110 - 120℃; for 4h;88.5%
1-ethyl-2-pyrrolidinemethanamine
26116-12-1

1-ethyl-2-pyrrolidinemethanamine

methyl 2-methoxy-5-sulfamoyl-benzoate
33045-52-2

methyl 2-methoxy-5-sulfamoyl-benzoate

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

Conditions
ConditionsYield
In glycerol at 90 - 95℃; for 10h; Inert atmosphere;88.4%
In ethylene glycol at 90 - 100℃; Solvent; Inert atmosphere;85.1%
at 100℃; for 3h;75%
C15H21N4O2(1+)*BF4(1-)

C15H21N4O2(1+)*BF4(1-)

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

Conditions
ConditionsYield
With sodium metabisulfite; sodium azide; tetrabutylammomium bromide; triphenylphosphine In water; acetonitrile at 80℃; for 12h; Inert atmosphere;60%
With sodium metabisulfite; sodium azide; tetrabutylammomium bromide; triphenylphosphine In water; acetonitrile at 80℃; for 4h; Inert atmosphere; Schlenk technique;60%
1-hydroxy-pyrrolidine-2,5-dione
6066-82-6

1-hydroxy-pyrrolidine-2,5-dione

2-methoxy-5-sulfamoylbenzoic acid
22117-85-7

2-methoxy-5-sulfamoylbenzoic acid

N-hydroxysuccinimido diphenyl phosphate
75513-55-2

N-hydroxysuccinimido diphenyl phosphate

N-ethyl-2-aminomethylpyrrole
74402-54-3

N-ethyl-2-aminomethylpyrrole

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

Conditions
ConditionsYield
With triethylamine In acetonitrile24%
1-ethyl-2-(nitromethylene)pyrrolidine

1-ethyl-2-(nitromethylene)pyrrolidine

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 76 percent / hydrogen / Raney nickel / methanol / 5 h / 85 °C / 52504.2 Torr
2: 75 percent / 3 h / 100 °C
View Scheme
1-ethyl-2-pyrrolidinemethanamine
26116-12-1

1-ethyl-2-pyrrolidinemethanamine

2-methoxy-5-sulfamoylbenzoic acid
22117-85-7

2-methoxy-5-sulfamoylbenzoic acid

1-methanesulfonyloxy-1,2,3-benzotriazole
54769-22-1

1-methanesulfonyloxy-1,2,3-benzotriazole

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

Conditions
ConditionsYield
With ammonium hydroxide; triethylamine In tetrahydrofuran; hydrogenchloride
C28H34N5O6S(1+)

C28H34N5O6S(1+)

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: dichloromethane; water / 12 h / 20 °C
2: aq. buffer / pH 7.2 / Irradiation
View Scheme
1-((8-cyano-7-hydroxyquinolin-2-yl)methyl)-1-ethyl-2-((2-methoxy-5-sulfamoylbenzamido)methyl)pyrrolidin-1-ium 2,2,2-trifluoroacetate

1-((8-cyano-7-hydroxyquinolin-2-yl)methyl)-1-ethyl-2-((2-methoxy-5-sulfamoylbenzamido)methyl)pyrrolidin-1-ium 2,2,2-trifluoroacetate

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

Conditions
ConditionsYield
In aq. buffer pH=7.2; Irradiation;
N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

methyl iodide
74-88-4

methyl iodide

2-<(2-methoxy-5-sulfamoylbenzamido)methyl>-1-ethyl-1-methylpyrrolidinium iodide

2-<(2-methoxy-5-sulfamoylbenzamido)methyl>-1-ethyl-1-methylpyrrolidinium iodide

Conditions
ConditionsYield
In acetonitrile for 2h; Heating;94.6%
methanol
67-56-1

methanol

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

ethyl 4-methoxy-3-(((1-methylpyrrolidin-2-yl)methyl)carbamoyl)benzenesulfonate

ethyl 4-methoxy-3-(((1-methylpyrrolidin-2-yl)methyl)carbamoyl)benzenesulfonate

Conditions
ConditionsYield
With pyrylium tetrafluoroborate In tert-butyl alcohol at 60℃; for 3h;90%
N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

ethyl iodide
75-03-6

ethyl iodide

2-<(2-methoxy-5-sulfamoylbenzamido)methyl>-1,1-diethylpyrrolidinium iodide
118894-83-0

2-<(2-methoxy-5-sulfamoylbenzamido)methyl>-1,1-diethylpyrrolidinium iodide

Conditions
ConditionsYield
In acetonitrile for 6.5h; Heating;82.6%
copper(II) choride dihydrate

copper(II) choride dihydrate

water
7732-18-5

water

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

[Cu(chloride)2(2-methoxy-5-sulphamoyl-N-((1-ethylpyrrolidin-2-yl)methyl)benzamide)2(water)2]*(water)
1235753-77-1

[Cu(chloride)2(2-methoxy-5-sulphamoyl-N-((1-ethylpyrrolidin-2-yl)methyl)benzamide)2(water)2]*(water)

Conditions
ConditionsYield
In ethanol; water addn. of hot (60°C) soln. of Cl compd. in ethanol/water (1:1) to hot (60°C) soln. of C compd. in ethanol/water (1:1), stirring under reflux for 2 h; filtration, washing with ethanol/water (1:1) and diethyl ether, elem. anal.;75%
water
7732-18-5

water

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

manganese(ll) chloride

manganese(ll) chloride

[Mn(chloride)2(2-methoxy-5-sulphamoyl-N-((1-ethylpyrrolidin-2-yl)methyl)benzamide)2(water)2]*2(water)

[Mn(chloride)2(2-methoxy-5-sulphamoyl-N-((1-ethylpyrrolidin-2-yl)methyl)benzamide)2(water)2]*2(water)

Conditions
ConditionsYield
In ethanol; water addn. of hot (60°C) soln. of Cl compd. in ethanol/water (1:1) to hot (60°C) soln. of C compd. in ethanol/water (1:1), stirring under reflux for 2 h; filtration, washing with ethanol/water (1:1) and diethyl ether, elem. anal.;72%
zinc(II) chloride dihydrate

zinc(II) chloride dihydrate

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

[Zn(chloride)2(2-methoxy-5-sulphamoyl-N-((1-ethylpyrrolidin-2-yl)methyl)benzamide)2(water)2]
1235753-79-3

[Zn(chloride)2(2-methoxy-5-sulphamoyl-N-((1-ethylpyrrolidin-2-yl)methyl)benzamide)2(water)2]

Conditions
ConditionsYield
In ethanol; water addn. of hot (60°C) soln. of Cl compd. in ethanol/water (1:1) to hot (60°C) soln. of C compd. in ethanol/water (1:1), stirring under reflux for 2 h; filtration, washing with ethanol/water (1:1) and diethyl ether, elem. anal.;70%
N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

3-(((N-ethyl-2-pyrrolidinyl)methyl)carbamoyl)-4-methoxybenzenesulfonyl fluoride

3-(((N-ethyl-2-pyrrolidinyl)methyl)carbamoyl)-4-methoxybenzenesulfonyl fluoride

Conditions
ConditionsYield
With potassium fluoride; pyrylium tetrafluoroborate; magnesium chloride In acetonitrile at 60℃; for 2h;69%
nickel(II) chloride hexahydrate

nickel(II) chloride hexahydrate

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

[Ni(chloride)2(2-methoxy-5-sulphamoyl-N-((1-ethylpyrrolidin-2-yl)methyl)benzamide)2(water)2]*(water)
1235753-75-9

[Ni(chloride)2(2-methoxy-5-sulphamoyl-N-((1-ethylpyrrolidin-2-yl)methyl)benzamide)2(water)2]*(water)

Conditions
ConditionsYield
In ethanol; water addn. of hot (60°C) soln. of Cl compd. in ethanol/water (1:1) to hot (60°C) soln. of C compd. in ethanol/water (1:1), stirring under reflux for 2 h; filtration, washing with ethanol/water (1:1) and diethyl ether, elem. anal.;68%
iron(III) chloride hexahydrate

iron(III) chloride hexahydrate

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

[Fe(chloride)2(2-methoxy-5-sulphamoyl-N-((1-ethylpyrrolidin-2-yl)methyl)benzamide)2(water)2](chloride)*(water)
1235753-71-5

[Fe(chloride)2(2-methoxy-5-sulphamoyl-N-((1-ethylpyrrolidin-2-yl)methyl)benzamide)2(water)2](chloride)*(water)

Conditions
ConditionsYield
In ethanol; water addn. of hot (60°C) soln. of Cl compd. in ethanol/water (1:1) to hot (60°C) soln. of C compd. in ethanol/water (1:1), stirring under reflux for 2 h; filtration, washing with ethanol/water (1:1) and diethyl ether, elem. anal.;68%
cobalt(II) chloride hexahydrate

cobalt(II) chloride hexahydrate

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

[Co(chloride)2(2-methoxy-5-sulphamoyl-N-((1-ethylpyrrolidin-2-yl)methyl)benzamide)2(water)2]*(water)
1235753-73-7

[Co(chloride)2(2-methoxy-5-sulphamoyl-N-((1-ethylpyrrolidin-2-yl)methyl)benzamide)2(water)2]*(water)

Conditions
ConditionsYield
In ethanol; water addn. of hot (60°C) soln. of Cl compd. in ethanol/water (1:1) to hot (60°C) soln. of C compd. in ethanol/water (1:1), stirring under reflux for 2 h; filtration, washing with ethanol/water (1:1) and diethyl ether, elem. anal.;62%
N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

6-((bis-(tert-butyl))phosphono-difluoromethyl)-2-naphthoic acid
219316-47-9

6-((bis-(tert-butyl))phosphono-difluoromethyl)-2-naphthoic acid

[(6-{3-[(1-ethyl-pyrrolidin-2-ylmethyl)-carbamoyl]-4-methoxy-benzenesulfonylaminocarbonyl}-naphthalen-2-yl)-difluoro-methyl]-phosphonic acid di-tert-butyl ester

[(6-{3-[(1-ethyl-pyrrolidin-2-ylmethyl)-carbamoyl]-4-methoxy-benzenesulfonylaminocarbonyl}-naphthalen-2-yl)-difluoro-methyl]-phosphonic acid di-tert-butyl ester

Conditions
ConditionsYield
With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride
N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

[(6-{3-[(1-ethyl-pyrrolidin-2-ylmethyl)-carbamoyl]-4-methoxy-benzenesulfonylaminocarbonyl}-naphthalen-2-yl)-difluoro-methyl]-phosphonic acid

[(6-{3-[(1-ethyl-pyrrolidin-2-ylmethyl)-carbamoyl]-4-methoxy-benzenesulfonylaminocarbonyl}-naphthalen-2-yl)-difluoro-methyl]-phosphonic acid

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: EDCI; DMAP
2: TFA
View Scheme
acetic anhydride
108-24-7

acetic anhydride

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

5-Acetylsulfamoyl-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-benzamide

5-Acetylsulfamoyl-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-benzamide

Conditions
ConditionsYield
With triethylamine at 20℃;
N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

propionic acid anhydride
123-62-6

propionic acid anhydride

N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-propionylsulfamoyl-benzamide

N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-5-propionylsulfamoyl-benzamide

Conditions
ConditionsYield
With triethylamine at 20℃;
Reaxys ID: 11328403

Reaxys ID: 11328403

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

Reaxys ID: 12226576

Reaxys ID: 12226576

Conditions
ConditionsYield
With triethylamine
(8-cyano-7-(methoxymethoxy)quinolin-2-yl)methyl methanesulfonate
1417436-71-5

(8-cyano-7-(methoxymethoxy)quinolin-2-yl)methyl methanesulfonate

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide
15676-16-1

N-[(1-ethyl-2-pyrrolidinyl)methyl]-2-methoxy-5-sulfamoylbenzamide

C28H34N5O6S(1+)

C28H34N5O6S(1+)

Conditions
ConditionsYield
In acetonitrile for 12h; Reflux;

15676-16-1Related news

Original ResearchThe Effect of Sulpiride (cas 15676-16-1) Treatment During the Periovulatory Period on Prolactin Concentration and Ovulation in the Mare09/06/2019

Sixteen estrous cycles from 10 cyclic mares were randomly assigned to a control or sulpiride group (n = 8 each). All mares received 1,500 IU of human chorionic gonadotropin (hCG) (hour 0) during estrus with a follicular diameter ≥32 mm. Mares were scanned every 12 hours until ovulation. In the ...detailed

Sulpiride (cas 15676-16-1) microemulsions as antipsychotic nasal drug delivery systems: In-vitro and pharmacodynamic study09/03/2019

The present study aimed to develop microemulsion (ME) formulae for nasal delivery of sulpiride with high drug concentration to overcome sulpiride low oral bioavailability. Different oils, surfactants (S) and co-surfactants (CoS) were screened for the highest sulpiride solubilizing capacity. Glyc...detailed

Original ResearchAssociation of Deslorelin and Sulpiride (cas 15676-16-1) for Double Ovulation Induction in Mares09/02/2019

The aim of this study was to verify the effect of deslorelin and sulpiride association on double ovulation induction in mares. Ten mares were used for this study. Eight days after ovulation, luteolysis was induced and mares were submitted a daily ultrasonographic evaluation until observation of ...detailed

Original ResearchEffects of Various Methods of Sulpiride (cas 15676-16-1) Administration on Prolactin Release in Horses09/01/2019

Four experiments assessed factors affecting prolactin responses to sulpiride administration in horses. Experiment 1 compared the efficacy of the (−) enantiomer of sulpiride to that of the commonly used (+/−) racemic mixture. Mares were used in an 8 × 8 Latin square to compare the prolactin resp...detailed

15676-16-1Relevant articles and documents

Photoactivatable Dopamine and Sulpiride to Explore the Function of Dopaminergic Neurons and Circuits

Asad, Naeem,Condon, Alec F.,Dore, Timothy M.,Gore, Sangram,Hampton, Shahienaz E.,Mclain, Duncan E.,Vijay, Sauparnika,Williams, John T.

, p. 939 - 951 (2020)

Kinetic analysis of dopamine receptor activation and inactivation and the study of dopamine-dependent signaling requires precise simulation of the presynaptic release of the neurotransmitter dopamine and tight temporal control over the release of dopamine receptor antagonists. The 8-cyano-7-hydroxyquinolinyl (CyHQ) photoremovable protecting group was conjugated to dopamine and the dopamine receptor antagonist sulpiride to generate "caged" versions of these neuromodulators (CyHQ-O-DA and CyHQ-sulpiride, respectively) that could release their payloads with 365 or 405 nm light or through 2-photon excitation (2PE) at 740 nm. These compounds are stable under physiological conditions in the dark, yet photolyze rapidly and cleanly to yield dopamine or sulpiride and the caging remnant CyHQ-OH. CyHQ-O-DA mediated the light activation of dopamine-1 (D1) receptors on the breast cancer cell line MDA-MB-231 in culture. In mouse brain slice from the substantia nigra pars compacta, localized flash photolysis of CyHQ-O-DA accurately mimicked the natural presynaptic release of dopamine and activation of dopamine-2 (D2) receptors, causing a robust, concentration-dependent, and repeatable G protein-coupled inwardly rectifying potassium channel-mediated outward current in whole-cell voltage clamp recordings that was amplified by cocaine and blocked by sulpiride. Photolysis of CyHQ-sulpiride rapidly blocked synaptic activity, enabling measurement of the unbinding rates of dopamine and quinpirole, a D2 receptor agonist. These tools will enable more detailed study of dopamine receptors, their interactions with other GPCRs, and the physiology of dopamine signaling in the brain.

A postoperative or its optical isomers of synthetic and post-processing method

-

Paragraph 0024; 0025, (2018/09/11)

The invention relates to a synthesis and post-processing method of sulpiride or an optical isomer thereof, and the synthesis and post-processing method include the following steps: under inert gas protection, heating 2-methoxy-5-aminosulfonyl methyl benzoate or 2-methoxy-5-aminosulfonyl ethyl benzoate and 1-ethyl-2-aminomethyl pyrrolidine or an optical isomer thereof at 80-120 DEG C for a plurality of hours, and after the reaction is completed, adding ethanol for processing, cooling, filtering, washing and drying.

A method for preparing shu Bili (by machine translation)

-

Paragraph 0013; 0014; 0015, (2017/02/17)

The invention discloses a method for preparing sulpiride. The method comprises the following steps: firstly, carrying out condensation reaction on 2-methoxy-5-aminosulfanoyl methyl benzoate and N-ethyl-2-aminomethyl tetrahydropyrrole to generate a crude sulpiride product; and refining the crude sulpiride product to obtain a refined sulpiride product. The sulpiride prepared by the method has the advantages of good quality, high purity, simple preparation method, low energy consumption and low cost.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 15676-16-1