1567768-48-2Relevant academic research and scientific papers
Synthesis and properties of double-stranded RNA-bindable oligodiaminogalactose derivatives conjugated with vitamin e
Iwata, Rintaro,Nishina, Kazutaka,Yokota, Takanori,Wada, Takeshi
, p. 1394 - 1403 (2014/03/21)
RNA interference (RNAi) is a gene-regulating system that is controlled by external short interfering RNAs (siRNAs). Sequence selective gene silencing by siRNA shows promise in clinical research. However, there have been few efficient methods for delivering siRNAs to target cells. In this study, we propose a novel type of RNA duplex-bindable molecule with an oligodiaminosaccharide structure. These 2,6-diamino-2,6-dideoxy-(1-4)-β-d-galactopyranose oligomers (oligodiaminogalactoses; ODAGals) conjugated with α-tocopherol (vitamin E; VE) or a VE analog were designed as novel siRNA-bindable molecules that can be utilized to deliver RNAi drugs to the liver. Among these compounds, the VE analog-bound ODAGal was suggested to bind to RNA duplexes without inhibiting RNAi activity.
