1567797-58-3Relevant academic research and scientific papers
Highly enantioselective synthesis of α-azido-β-hydroxy methyl ketones catalyzed by a cooperative proline-guanidinium salt system
Martinez-Castaneda, Angel,Kedziora, Kinga,Lavandera, Ivan,Rodriguez-Solla, Humberto,Concellon, Carmen,Del Amo, Vicente
, p. 2598 - 2600 (2014)
The combined activity of (S)-proline and an achiral tetraphenylborate TBD-derived guanidinium salt permits the aldol reaction between azidoacetone and aromatic, or heteroaromatic aldehydes. The α-azido-β-hydroxy methyl ketones obtained as products can be isolated in good yield, with high diastereo- and enantioselectivity. The Royal Society of Chemistry 2014.
