1568113-64-3Relevant academic research and scientific papers
Method for efficiently synthesizing trifluoromethyl compound, the trifluoromethyl compound and application
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Paragraph 0105-0110, (2020/06/20)
The invention relates to a method for efficiently synthesizing a trifluoromethyl compound, the trifluoromethyl compound and application. The method comprises directly synthesizing an alpha-trifluoromethyl carbonyl compound in one step under the action of a catalyst by adopting halogen substituted ketene and a Togni reagent as raw materials, wherein X is independently selected from halogen, O, S and N elements; R1 is independently selected from aryl, electron-donating or electron-withdrawing substituted aryl and C1-C6 straight-chain or branched-chain alkyl; and R2 is independently selected fromaryl, electron-donating or electron-withdrawing substituted aryl. The method has the obvious advantages of high raw material conversion rate and high yield of the obtained product, and the conversionhas irreplaceable value in bioactive molecules and plays an important role in medicinal chemistry.
Catalytic C-H α-trifluoromethylation of α,β-unsaturated carbonyl compounds
Fang, Zhongxue,Ning, Yongquan,Mi, Pengbing,Liao, Peiqiu,Bi, Xihe
supporting information, p. 1522 - 1525 (2014/04/03)
A copper(I)-catalyzed, regioselective C-H α-trifluoromethylation of α,β-unsaturated carbonyl compounds using Togni's reagent was developed. Diverse substrates, including enones as well as α,β- unsaturated esters, thioesters, and amides, stereospecifically afforded the corresponding (E)-α-trifluoromethylated products in moderate to high yields. Further, this method was applied to the C-H trifluoromethylation of drugs.
