156817-94-6Relevant articles and documents
Preparation method of 4-ethyl-5-aminopyrimidine
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Paragraph 0028-0029; 0032-0036; 0039-0042; 0045-0046, (2021/07/31)
The invention discloses 4-ethyl-5-aminopyrimidine. A preparation method comprises the following specific steps: (1) taking 4-bromo-5-aminopyrimidine and tributyl vinyl tin as initial raw materials, and carrying out Schpeller coupling reaction to prepare the 4-vinyl-5-aminopyrimidine; and (2) taking the 4-vinyl-5-aminopyrimidine as an initial raw material, and carrying out palladium-carbon hydrogenation reaction to prepare the 4-ethyl-5-aminopyrimidine. The method is short in process route, few in reaction reagent types, convenient to operate, mild in reaction condition and easy to control, industrialization is easy to achieve, the product is easy to purify, the yield is high, and unreported molecules provide more possibilities for new drug research and development work.