156833-28-2

Upstream product

• 66-77-3 1-naphthaldehyde 
• 96797-15-8 N-trityl-4⁽⁵⁾-iodoimidazole 
• 925-90-6 ethylmagnesium bromide 
• 156833-32-8 4-<(1-naphthyl)carbonyl>-N-(triphenylmethyl)imidazole 
• 703-55-9 1-naphthylmagnesiumbromide 
• 33016-47-6 (1-tritylimidazol-4-yl)carboxaldehyde 

Downstream Products

• 156833-35-1 4-<(1-naphthyl)(trifluoromethyl)hydroxymethyl>-N-(triphenylmethyl)imidazole 
• 178556-71-3 1-Naphthalen-1-yl-1-(1-trityl-1H-imidazol-4-yl)-propan-1-ol 
• 178556-77-9 1-naphthalen-1-yl-1-(1-trityl-1H-imidazol-4-yl)-ethanol 
• 156833-32-8 4-<(1-naphthyl)carbonyl>-N-(triphenylmethyl)imidazole 

Relevant academic research and scientific papers

PYRIDINE COMPOUNDS AS SUBTYPE SELECTIVE MODULATORS OF ALPHA2B AND/OR ALPHA 2C ADRENERGIC RECEPTORS

The invention relates specifically to the use of certain 4-[1-(1H-Imidazol-4-yl)-ethyl]-2,3-substituted pyridine compounds and pharmaceutical compositions thereof to treat disorders associated with selective subtype alpha 2 adrenergic receptor modulation.

Medetomidine analogs as α2-adrenergic ligands. 2. Design, synthesis, and biological activity of conformationally restricted naphthalene derivatives of medetomidine

A new series of naphthalene analogs of medetomidine have been prepared and evaluated for their α-adrenergic activities. The methylnaphthyl analog 5a showed significant selectivity for α2-adrenoceptors and behaved as a partial α1-agonist in rat aorta preparations. In contrast, the Z-ethylene analog 8c was α1-selective and behaved as a potent α1-antagonist. Two rigid analogs (6 and 7) exhibited large differences in binding affinities at α1- vs α2-receptors, indicating that the conformational flexibility of 5a is important for the fulfillment of the α-adrenergic activities. Molecular modeling studies began with conformational analysis of classical phenethylamines and medetomidine analogs. Superimposition of medetomidine conformations with those of phenethylamines provided a tentative explanation for the α2-adrenergic activity of the new imidazoles. A common binding mode for phenethylamines and imidazoles with α2-adrenoceptors is proposed. Knowledge of the biological properties of the 4-substituted imidazoles, integrated with the information derived from computer-assisted molecular modeling, has provided new insights for the structural and conformational requirements of this class as new adrenergic drugs.

A Structure-Activity Relationship Study of Benzylic Modifications of 4--1H-imidazoles on α1- and α2-Adrenergic Receptors

The naphthalene analog of medetomidine (1), 4--1H-imidazole (2), is a highly potent, selective α2-adrenoceptor agonist.We have initiated a structure-activity relationship study of the replacement of the methyl group on the