156868-83-6

Basic information

• Product Name: 3-(3-FLUORO-PHENYL)-PROPAN-1-OL
• Synonyms: 3-(3-FLUORO-PHENYL)-PROPAN-1-OL;Benzenepropanol, 3-fluoro- (9CI)
• CAS NO: 156868-83-6
• Molecular Formula: C₉H₁₁FO
• Molecular Weight: 154.1814432
• Product Categories: HALIDE
• Mol File: 156868-83-6.mol
• Article Data: 17

Chemical Properties

• Boiling Point: 234.162°C at 760 mmHg
• Flash Point: 116.828°C
• Appearance: /
• Density: 1.098g/cm³
• Vapor Pressure: 0.03mmHg at 25°C
• Refractive Index: 1.509
• CAS DataBase Reference: 3-(3-FLUORO-PHENYL)-PROPAN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3-FLUORO-PHENYL)-PROPAN-1-OL(156868-83-6)
• EPA Substance Registry System: 3-(3-FLUORO-PHENYL)-PROPAN-1-OL(156868-83-6)

Safety Data

• Hazardous Substances Data: 156868-83-6(Hazardous Substances Data)

Usage

InChI:InChI=1/C9H11FO/c10-9-5-1-3-8(7-9)4-2-6-11/h1,3,5,7,11H,2,4,6H2

Upstream product

• 75-21-8 oxirane 
• 456-41-7 1-(Bromomethyl)-3-fluorobenzene 
• 425704-52-5 methyl 3-(3-fluorophenyl)propanoate 
• 20595-30-6 3-Fluorocinnamic acid 
• 30984-53-3 1-allyl-3-fluorobenzene 
• 17318-03-5 bromo(3-fluorophenyl)magnesium 
• 74325-03-4 methyl (E)-m-fluorocinnamate 
• 456-48-4 3-Fluorobenzaldehyde 
• 458-45-7 3-(3-fluorophenyl)propionic acid 
• 304-59-6 Rochelle's salt 
• 59223-73-3 diethyl 2-(3-fluorobenzyl)malonate 
• 7116-37-2 ethyl 3-(3-fluorophenyl)propanoate 

Downstream Products

• 245070-85-3 3-(3-fluorophenyl)propanal 
• 1597430-38-0 3-fluorophenylpropyloxyamine hydrochloride 
• 1597430-54-0 C₁₈H₂₂FN₃O₆ 
• 1197396-83-0 2-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-3H,8H-2a,5,8a-triazaacenaphthylene-3,8-dione 
• 1073495-62-1 (1R)-9-fluoro-1-[(4-{[3-(3-fluorophenyl)propyl]amino}-1-piperidinyl)methyl]-1,2-dihydro-4H-pyrrolo[3,2,1-ij]quinolin-4-one 
• 104774-86-9 3-(3-fluorophenyl)-propan-1-amine 
• 847585-23-3 1-({6-[3-(3-fluorophenyl)propoxy]-1-methyl-3,4-dihydro-2-naphthalenyl}methyl)-3-azetidinecarboxylic acid hydrochloride 
• 847736-94-1 C₂₅H₂₈FNO₃ 
• 1355088-68-4 C₂₁H₂₁FO₂ 

Relevant articles and documents

Synthesis and inhibitory studies of phosphonic acid analogues of homophenylalanine and phenylalanine towards alanyl aminopeptidases

A library of novel phosphonic acid analogues of homophenylalanine and phenylalanine, containing fluorine and bromine atoms in the phenyl ring, have been synthesized. Their inhibitory properties against two important alanine aminopeptidases, of human (hAPN, CD13) and porcine (pAPN) origin, were evaluated. Enzymatic studies and comparison with literature data indicated the higher inhibitory potential of the homophenylalanine over phenylalanine derivatives towards both enzymes. Their inhibition constants were in the submicromolar range for hAPN and the micromolar range for pAPN, with 1-amino-3-(3-fluorophenyl) propylphosphonic acid (compound 15c) being one of the best low-molecular inhibitors of both enzymes. To the best of our knowledge, P1 homophenylalanine analogues are the most active inhibitors of the APN among phosphonic and phosphinic derivatives described in the literature. Therefore, they constitute interesting building blocks for the further design of chemically more complex inhibitors. Based on molecular modeling simulations and SAR (structure-activity relationship) analysis, the optimal architecture of enzyme-inhibitor complexes for hAPN and pAPN were determined.

2-AMINOQUINOLINE-BASED COMPOUNDS FOR POTENT AND SELECTIVE NEURONAL NITRIC OXIDE SYNTHASE INHIBITION

Various 2-aminoquinoline compounds as can be used, in vivo or in vitro, for selective inhibition of neuronal nitric oxide synthase.

BENZOXAZOLONE DERIVATIVES AS ACID CERAMIDASE INHIBITORS, AND THEIR USE AS MEDICAMENTS

The present invention relates to benzoxazolone derivatives as acid ceramidase inhibitors, pharmaceutical compositions containing these inhibitors and methods of inhibiting acid ceramidase for the treatment of disorders in which modulation of the levels of ceramide is clinically relevant. The invention also provides benzoxazolone derivatives for use as a medicament in the treatment of cancer, inflammation, pain, inflammatory pain or pulmonary diseases.