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15687-27-1

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Product FOB Price Min.Order Supply Ability Supplier
Ibuprofen
Cas No: 15687-27-1
No Data 1 Metric Ton 200 Metric Ton/Day Shaanxi WuZhiYuan Biological Technology Co.,Ltd Contact Supplier
Ibuprofen
Cas No: 15687-27-1
No Data No Data No Data SHINING HEALTH GROUP LIMITED Contact Supplier
Top Supplier Ibuprofen 99%
Cas No: 15687-27-1
USD $ 1.0-1.0 / Kilogram 1 Kilogram 10000 Kilogram/Year Shanghai Upbio Tech Co.,Ltd Contact Supplier
15687-27-1
Cas No: 15687-27-1
No Data 1 Kilogram 5000 Kilogram/Month Weifang Tansen Yiang international trading co., LTD Contact Supplier
Ibuprofen CAS:15687-27-1
Cas No: 15687-27-1
No Data No Data Metric Ton/Day Shanghai Ingredients Technology Co., Ltd. Contact Supplier
Ibuprofen Manufacturer/High quality/Best price/In stock
Cas No: 15687-27-1
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Hangzhou Dayangchem Co., Ltd. Contact Supplier
Ibuprofen α-Methyl-4-(isobutyl)phenylacetic acid
Cas No: 15687-27-1
USD $ 1.0-3.0 / Kilogram 1 Kilogram 10 Kilogram/Day Hebei yanxi chemical co.,LTD. Contact Supplier
Ibuprofen CAS NO.15687-27-1
Cas No: 15687-27-1
No Data 1 Kilogram 500~1000 Kilogram/Month Hubei Jusheng Technology Co., Ltd., Contact Supplier
Top quality API powder Ibuprofen 15687-27-1 with reasonable price and fast delivery on hot selling
Cas No: 15687-27-1
USD $ 400.0-400.0 / Kilogram 1 Kilogram 400 Metric Ton/Day Kono Chem Co.,Ltd Contact Supplier
Factory supply Ibuprofen Cas 15687-27-1 with high quality and favorable price
Cas No: 15687-27-1
USD $ 22.0-25.0 / Kilogram 25 Kilogram 130 Metric Ton/Year Wuhan Fortuna Chemical Co.,Ltd Contact Supplier

15687-27-1 Usage

Increase stroke risk

Ibuprofen is one of the most commonly used non-prescription painkillers, commonly used in the treatment of arthritis, muscle pain, neuralgia, headache, migraine, toothache, dysmenorrhea or low back pain. A recent study published in the British Medical Journal found that people who have taken a large number of antipyretic drugs, ibuprofen, have a 3-fold increase in the risk of getting stroke or heart disease.
Researchers from the University of Berne in Switzerland reviewed 31 clinical trials involving more than 11.6 million patients. Patients were treated with one of seven common analgesics. The results showed that patients subjecting to long-term administration of large doses of ibuprofen not only have a risk of getting stroke increased by 3 times, but also have significantly increased risk of suffering heart attack and heart disease death. However, the study also showed that occasionally taking ibuprofen for the treatment of headache will not be dangerous. The study also found that commonly used analgesic diclofenac sodium also has a similar problem.
The study found a health risk associated with long-term use of ibuprofen, being similar to the anti-arthritis drug rofecoxib (Velcro), which was halted in 2004 due to safety concerns.

Uses

A selective cyclooxygenase inhibitor (IC50=14.9uM). Inhibits PGH synthase-1 and PGH synthase-2 with comparable potency

Uses

antiinflammatory

Chemical Properties

Colourless, Crystalline Solid

Indications

  • Alleviate the acute phase of various kinds of chronic arthritis such as rheumatoid arthritis, osteoarthritis, spondyloarthropathies, gouty arthritis and rheumatoid arthritis as well as persistent symptoms of joint swelling and pain. It can be used for the non-cause treatment and control of disease.
  • For the treatment of various kinds of non-joint soft tissue rheumatic pain, such as shoulder pain, tenosynovitis, bursitis, myalgia and post-exercise pain.
  • For the treatment of acute mild to moderate pain such as: post-surgery, post-trauma, post-strain, primary dysmenorrhea, toothache, headache and so on.
  • It has an antipyretic effect against the fever of adults and children.

Drug Interactions

  • Drinking or combination with other non-steroidal anti-inflammatory drugs can increase the gastrointestinal side effects, and have the risk of ulcers. Long-term combination with acetaminophen can increase the toxic side effects on the kidney.
  • Combination with aspirin or other salicylic acid drugs causes no increase in the efficacy, but cam cause gastrointestinal adverse reactions and increase of the bleeding tendency.
  • Combination with heparin, dicoumarol and other anticoagulants as well as platelet aggregation inhibitors has the risk for increasing bleeding.
  • Combination with furosemide can weaken the sodium excretion effect and antihypertensive effect.
  • Combination with verapamil and nifedipine can increase the plasma concentration of the product.
  • Ibuprofen can increase the plasma concentration of digoxin; pay attention to adjusting the dose of digoxin upon co-administration.
  • Ibuprofen can enhance the role of anti-diabetic drugs (including oral hypoglycemic agents).
  • The goods, when used in combination with antihypertensive drugs can affect the antihypertensive effect of the latter one.
  • Probenecid can reduce the excretion of the goods, increase the concentration of blood, thereby increasing the toxicity, so it is proper to reduce the dosage upon co-administration.
  • The goods can reduce the excretion of methotrexate, increase the blood concentration which can reach up to the level of poisoning, so the goods should not be used with medium or large doses of methotrexate.

Definition

ChEBI: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(2-methylpropyl)phenyl group.

description

Ibuprofen belongs to a non-steroidal anti-inflammatory analgesic. It has excellent anti-inflammatory, analgesic and antipyretic effect with less adverse reactions. It has been widely used in the world, as the world's best-selling non-prescription drugs. It, together with aspirin and paracetamol are listed as the three key antipyretic analgesics products. In our country, it is mainly used in pain alleviation and anti-rheumatism, etc. It has much less applications in the treatment of cold and fever compared with paracetamol and aspirin. There are a dozens of pharmaceutical companies qualified for production of ibuprofen in China. But the bulk of the domestic market sales of ibuprofen have been occupied by Tianjin Sino-US Company.
The Ibuprofen was co-discovered by Dr. Stewart Adams (later he becomes a professor and won the Medal of the British Empire) and his team including CoLinBurrows and Dr. John Nicholson. The aim of the initial study was to develop a "super aspirin" to obtain an alternative for the treatment of rheumatoid arthritis that is comparable to that of aspirin but with less serious adverse reactions. For other drugs such as phenylbutazone, it has a high risk of causing adrenal suppression and other adverse events such as gastrointestinal ulcers. Adams decided to look for a drug with good gastrointestinal resistance, which is particularly important for all non-steroidal anti-inflammatory drugs.
Phenyl acetate drugs have aroused people's interest. Although some of these drugs have been found to be at risk of causing ulcers based on the dog's test, Adams is aware of that this phenomenon may be due to a relatively long half-life of the drug clearance. In this class of drugs there is a compound – ibuprofen, which has a relatively short half-life, sustaining only 2 hours. Among the screened alternative drugs, although it is not the most effective, it is the most secure. In 1964, ibuprofen had become the most promising alternative to aspirin.

Used in Particular Diseases

Acute Gouty Arthritis:
Dosage and Frequency: 800 mg four times a day

Precautions

1.For late pregnancy women, it can prolong the pregnancy, causing dystocia and prolonged pregnancy course. Pregnant women and lactating women should not administrate it.
2. Inhibition of platelet aggregation; it can extent the bleeding time. This effect will disappear at 24 hours after withdrawal of the drug.
3. It can increase the blood urea nitrogen and serum creatinine content, further reducing the creatinine clearance rate. The following circumstances should be used with caution:
  • Bronchial asthma can be aggravated after treatment.
  • Heart failure, high blood pressure; medication can cause water retention, edema.
  • Hemophilia or other hemorrhagic diseases (including coagulation disorders and platelet dysfunction); medication can cause prolonged bleeding time, increase the bleeding tendency.
  • Patients with a history of gastrointestinal ulcers are prone to get gastrointestinal side effects, including generating new ulcers.
  • Patients of renal dysfunction, after administration, can get increased renal adverse reactions, and even get renal failure.
  • During long-term medication, it should be regularly checked of blood phase and liver, kidney function.

Side Effects

  • Gastrointestinal symptoms include indigestion, stomach burning sensation, stomach pain and nausea as well as vomiting. This usually appears in 16% long-term administrators. These symptoms will disappear upon drug withdraw. In most cases, the patients can tolerate even without withdrawal. A small number (<1%) of patients can get gastric ulcer and gastrointestinal bleeding. This are also cases of perforation due to ulcer.
  • Neurological symptoms such as headache, lethargy and dizziness; Tinnitus (rare) appears in 1% to 3% of patients.
  • Renal insufficiency is rare, mostly occur in patients of potential kidney disease; but a small number of patients may obtain lower extremity edema.
  • Other rare symptoms also include rash, bronchial asthma attack, elevated liver enzymes and leukopenia.
  • During medication, there might be emergence of gastrointestinal bleeding, liver and kidney dysfunction, visual impairment, abnormal blood and allergic reactions, etc., that should be discontinued.

Uses

Antibiotic
InChI:InChI=1/C13H18O2/c1-9(2)8-11-4-6-12(7-5-11)10(3)13(14)15/h4-7,9-10H,8H2,1-3H3,(H,14,15)/p-1/t10-/m1/s1

15687-27-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Sigma (I110)  Ibuprofen   15687-27-1 I110-5G 1,296.36CNY Detail
Sigma (I110)  Ibuprofen   15687-27-1 I110-1G 439.92CNY Detail
Cerilliant (I-009)  Ibuprofensolution  1.0 mg/mL in methanol, ampule of 1 mL, certified reference material 15687-27-1 I-009-1ML 366.21CNY Detail
Sigma (I4883)  Ibuprofen  ≥98% (GC) 15687-27-1 I4883-10G 2,321.28CNY Detail
Sigma (I4883)  Ibuprofen  ≥98% (GC) 15687-27-1 I4883-5G 1,350.18CNY Detail
Sigma (I4883)  Ibuprofen  ≥98% (GC) 15687-27-1 I4883-1G 549.90CNY Detail
USP (1335508)  Ibuprofen  United States Pharmacopeia (USP) Reference Standard 15687-27-1 1335508-750MG 4,662.45CNY Detail
Sigma-Aldrich (Y0000881)  Ibuprofen for peak identification  European Pharmacopoeia (EP) Reference Standard 15687-27-1 Y0000881 1,880.19CNY Detail
Sigma-Aldrich (I0020000)  Ibuprofen  European Pharmacopoeia (EP) Reference Standard 15687-27-1 I0020000 1,880.19CNY Detail
Sigma-Aldrich (PHR1004)  Ibuprofen  pharmaceutical secondary standard; traceable to USP, PhEur, BP 15687-27-1 PHR1004-1G 732.19CNY Detail
Alfa Aesar (B20989)  4-Isobutyl-alpha-methylphenylacetic acid, 99%    15687-27-1 25g 4226.0CNY Detail
Alfa Aesar (B20989)  4-Isobutyl-alpha-methylphenylacetic acid, 99%    15687-27-1 5g 995.0CNY Detail

15687-27-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name ibuprofen

1.2 Other means of identification

Product number -
Other names Andran

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:15687-27-1 SDS

15687-27-1Downstream Products

15687-27-1Related news

Preparation and characterization of NiFe2O4/activated carbon composite as potential magnetic adsorbent for removal of Ibuprofen (cas 15687-27-1) and ketoprofen pharmaceuticals from aqueous solutions09/10/2019

NiFe2O4/activated carbon magnetic composite (NiAC) was produced by hydrothermal method, characterized and applied to adsorb the emerging contaminants ibuprofen and ketoprofen from diluted solutions. The study of the adsorption process was focused on the evaluation of pH effect, kinetic behavior,...detailed

Degradation of Ibuprofen (cas 15687-27-1) by UV-LED/catalytic advanced oxidation process09/09/2019

Ibuprofen (IBP), a widely used anti-inflammatory drug, has been detected in many rivers and lake waters. This study was aimed to degrade the ibuprofen from synthetic wastewater by using UV-LED/catalytic and UV-LED/oxidants advanced oxidation process. The degradation of IBP was investigated with ...detailed

Research PaperEvaluation of a modified mica and montmorillonite for the adsorption of Ibuprofen (cas 15687-27-1) from aqueous media09/08/2019

The goals of this work were to prepare and characterize two functional materials, a natural montmorillonite (Mt) and a synthetic mica (Na-mica-4) were modified with the cationic octadecylamine by a cation-exchange reaction between obtained C18-Mt and C18-mica-4, and to explore their potential us...detailed

Brief ObservationAltitude Sickness Prevention with Ibuprofen (cas 15687-27-1) Relative to Acetazolamide09/07/2019

BackgroundAcute mountain sickness is a common occurrence for travel to high altitudes. Although previous studies of ibuprofen have shown efficacy for the prevention of acute mountain sickness, recommendations have been limited, as ibuprofen has not been compared directly with acetazolamide until...detailed

Original articleUva-ursi extract and Ibuprofen (cas 15687-27-1) as alternative treatments for uncomplicated urinary tract infection in women (ATAFUTI): a factorial randomized trial09/06/2019

ObjectivesThe aim was to investigate if offering symptomatic therapy (Uva-ursi or ibuprofen) alongside a delayed prescription would relieve symptoms and reduce the consumption of antibiotics for adult women presenting with acute uncomplicated urinary tract infection (UTI).detailed

Research paperRepurposing Ibuprofen (cas 15687-27-1) to control Staphylococcus aureus biofilms09/04/2019

Drug repurposing arises as an interesting alternative to overcome the limited efficacy of current available antibiotics by reducing time, cost and risk associated with drug innovation. In this study, the activity of ibuprofen, a non-steroidal anti-inflammatory drug (NSAID), was evaluated on the ...detailed

The effects of intra-articular injection of Ibuprofen (cas 15687-27-1) on knee joint cartilage and synovium in rats09/03/2019

ObjectiveThe aim of this animal study was to investigate the short and long-term local histomorphologic effects and the utility of intra-articular application of ibuprofen.detailed

Biosorption of Ibuprofen (cas 15687-27-1) using functionalized bean husks09/01/2019

The ability of bean husk, an agricultural waste, as a promising adsorbent for sequestering Ibuprofen from aqueous solution was investigated. Bean husk waste was modified using ortho-phosphoric acid. The prepared adsorbent was further characterized using FTIR, SEM, EDX and pHpzc techniques respec...detailed

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