156904-85-7

Basic information

• Product Name: Acetic acid (S)-2-[(2-benzhydryl-4-oxo-4H-quinazolin-3-yl)-isobutyryl-amino]-1-methyl-2-oxo-ethyl ester
• CAS NO: 156904-85-7
• Molecular Weight: 511.577
• Mol File: 156904-85-7.mol

Chemical Properties

• CAS DataBase Reference: Acetic acid (S)-2-[(2-benzhydryl-4-oxo-4H-quinazolin-3-yl)-isobutyryl-amino]-1-methyl-2-oxo-ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Acetic acid (S)-2-[(2-benzhydryl-4-oxo-4H-quinazolin-3-yl)-isobutyryl-amino]-1-methyl-2-oxo-ethyl ester(156904-85-7)
• EPA Substance Registry System: Acetic acid (S)-2-[(2-benzhydryl-4-oxo-4H-quinazolin-3-yl)-isobutyryl-amino]-1-methyl-2-oxo-ethyl ester(156904-85-7)

Safety Data

• Hazardous Substances Data: 156904-85-7(Hazardous Substances Data)

Upstream product

• 79-30-1 isobutyryl chloride 
• 178422-79-2 3-<(S)-2-Acetoxypropanoyl>amino-2-diphenylmethyl-3,4-dihydroquinazolin-4-one 
• 178422-78-1 3-Amino-2-diphenylmethyl-3,4-dihydroquinazolin-4-one 
• 36394-75-9 (S)-2-acetoxypropanoyl chloride 

Relevant articles and documents

3-Di-[(S)-2-acetoxypropanoyl] aminoquinazolin-4(3H)-ones: Stereostructure and application in kinetic resolution of amines

Whereas 3-diacylaminoquinazolin-4(3H)-ones (DAQs) have been previously shown to undergo rapid exo/endo-endo/exo conformational interconversion of their imide carbonyl groups, the title DAQs are believed to exist in one single exo/endo form and consequently their N-N bonds are chiral axis: one of these DAQs, substituted with a diphenylmethyl group on the Q-2 position, reacts preferentially with one enantiomer of racemic 2-methyl-piperidine at the 2-acetoxypropanoyl imide carbonyl group (ee 94%). (C) 2000 Elsevier Science Ltd.

The N-N Bond as a Chiral Axis: 3-(Diacylamino)quinazolin-4(3H)ones as Chiral Acylating Agents

Two diastereoisomers of 3-(diacylamino)quinazolinone 5 are separated and identified by crystal structure determinations which confirm the presence of an N-N chiral axis: one diastereoisomer of enantiopure 8 reacts with racemic 1-phenylethylamine exclusive