1569091-45-7

Basic information

• Product Name: C₃₃H₂₅BrN₄O₂S
• Synonyms: C₃₃H₂₅BrN₄O₂S
• CAS NO: 1569091-45-7
• Molecular Weight: 621.557
• Mol File: 1569091-45-7.mol

Chemical Properties

• CAS DataBase Reference: C₃₃H₂₅BrN₄O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₃₃H₂₅BrN₄O₂S(1569091-45-7)
• EPA Substance Registry System: C₃₃H₂₅BrN₄O₂S(1569091-45-7)

Safety Data

• Hazardous Substances Data: 1569091-45-7(Hazardous Substances Data)

Upstream product

• 1287715-31-4 1-benzyl-3-isothiocyanatoindolin-2-one 

Relevant articles and documents

Quinine-catalyzed asymmetric domino Michael-cyclization reaction for the synthesis of spirocyclic oxindoles bearing two spiro quaternary centers and three consecutive stereocenters

An efficient organocatalytic diastereo- and enantioselective method for the construction of spirocyclic oxindole derivatives bearing two spiro quaternary centers and three consecutive stereocenters via a domino Michael/cyclization process has been developed. Using commercially available quinine as catalyst, the reactions of 3-isothiocyanato oxindoles with unsaturated pyrazolones and unsaturated isoxazolones proceeded smoothly under mild reaction conditions for giving two classes of spirocyclic oxindole compounds in high to excellent yields with moderate to good diastereoselectivities and enantioselectivities. A plausible dual activation working model was tentatively proposed to account for the stereochemistry of the domino Michael/cyclization process.