1569092-86-9Relevant articles and documents
Proline-tetrazole-catalyzed enantioselective N-nitroso aldol reaction of aldehydes with in situ generated nitrosocarbonyl compounds
Maji, Biplab,Yamamoto, Hisashi
, p. 8714 - 8717 (2014)
A highly enantioselective method (up to 98% ee) for the preparation of β-amino alcohols was achieved by using the readily available proline-tetrazole as the catalyst for the N-nitroso aldol reaction of aldehydes with in situ generated nitrosocarbonyl compounds. The key to success of this reaction is the use of MnO2 as an oxidant and catechol as a Bronsted acid additive.
Practical approach for asymmetric hydroxyamination of aldehydes with in situ generated nitrosocarbonyl compounds: Application to one-pot synthesis of chiral allylamines
Kano, Taichi,Shirozu, Fumitaka,Maruoka, Keiji
supporting information, p. 1530 - 1532 (2014/04/03)
The highly regio- and enantioselective hydroxyamination of aldehydes with in situ generated nitrosocarbonyl compounds from a hydroxamic acid derivative was realized by simple and readily available chiral amine catalysts. The resulting hydroxyamination products were readily converted to the corresponding chiral 1,2-aminoalcohol or allylamine derivatives in one pot.
