1569095-61-9Relevant articles and documents
An investigation of the asymmetric Huisgen 'click' reaction 1
Stephenson, G. Richard,Buttress, James P.,Deschamps, Damien,Lancelot, Mélanie,Martin, James P.,Sheldon, Alexander I. G.,Alayrac, Carole,Gaumont, Annie-Claude,Page, Philip C. Bulman
, p. 2723 - 2729 (2013)
The preparation of a series of new prochiral bis-alkynes is reported. A selection of chiral ligands is examined to gain additional information about the scope of the new asymmetric Huisgen 'click' reaction [the desymmetrisation of bis-alkynes using chiral ligands in conjunction with the widely applied copper-catalysed azide-alkyne cycloaddition (CuAAC) triazole synthesis]. The development of a new chiral assay for (±)-methyl 2-[(1-benzyl-1H-1,2,3- triazol-4-yl)methyl]-2-cyanopent-4-ynoate, and the production of this mono-triazole in up to 18% enantiomeric excess is described. Georg Thieme Verlag Stuttgart New York.