1569098-53-8Relevant articles and documents
One-pot DBU-promoted synthesis of hydroacridinones and spirohexahydropyrimidines
Neochoritis, Constantinos G.,Eleftheriadis, Nicolaos,Tsiantou, Arianna,Stephanidou-Stephanatou, Julia,Tsoleridis, Constantinos A.
, p. 2768 - 2772 (2013)
The potential hydroacridinone synthesis using simple and inexpensive starting materials, namely 1,3-dicarbonyl compounds, anilines, formaldehyde and DBU as a stoichiometric base was explored. As a result, from the reaction of 1,3-cyclohexanedione and dimedone tetrahydroacridinones were the main reaction products along with small yields of their oxidation products, the dihydroacridinones, whereas in the case of 2-acetylcyclohexanone spirohexahydropyrimidines were isolated in very good yields. Plausible mechanistic schemes for the formation of all products are proposed. Georg Thieme Verlag Stuttgart New York.