1569105-05-0Relevant articles and documents
Total synthesis of mersicarpine through a cationic cyclization approach
Lv, Zhe,Li, Zining,Liang, Guangxin
, p. 1653 - 1655 (2014)
A concise total synthesis of mersicarpine is achieved by exploiting a cyclic carbamate for generation of a tertiary carbocation. The key step involves intramolecular Friedel-Crafts alkylation with this carbocation for the construction of a quaternary carbon center and a subsequent oxidation and cyclization cascade for the formation of a seven-membered cyclic imine. The chemistry allowed for a rapid one-pot synthesis of mersicarpine from a simple intermediate using straightforward chemical operations.
