1569294-14-9

Basic information

• Product Name: C₂₅H₃₁⁽¹²⁵⁾IN₆O₂S
• CAS NO: 1569294-14-9
• Molecular Weight: 604.626
• Mol File: 1569294-14-9.mol

Chemical Properties

• CAS DataBase Reference: C₂₅H₃₁⁽¹²⁵⁾IN₆O₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₅H₃₁⁽¹²⁵⁾IN₆O₂S(1569294-14-9)
• EPA Substance Registry System: C₂₅H₃₁⁽¹²⁵⁾IN₆O₂S(1569294-14-9)

Safety Data

• Hazardous Substances Data: 1569294-14-9(Hazardous Substances Data)

Upstream product

• 1569294-07-0 N-(2-(N,N-diethylamino)ethyl)-6-(N-(2-((2-iodobenzyl)thio)ethyl)ureido)quinoxaline-2-carboxamide 

Relevant articles and documents

Synthesis and biological evaluation of new quinoxaline derivatives of ICF01012 as melanoma-targeting probes

The aim of this study was the synthesis and pharmacokinetic selection of a best melanin-targeting ligand for addressing anticancer agents to pigmented melanoma. Seven quinoxaline carboxamide derivatives were synthesized and radiolabeled with iodine-125. Biodistribution studies of compounds [ 125I]1a-g performed in melanoma-bearing mice tumor showed significant tumor uptake (range 2.43-5.68%ID/g) within 1 h after i.v. injection. Fast clearance of the radioactivity from the nontarget organs mainly via the urinary system gave high tumor-to-blood and tumor-to-muscle ratios. Given its favorable clearance and high tumor-melanoma uptake at 72 h, amide 1d was the most promising melanoma-targeting ligand in this series. Compound 1d will be used as building block for the design of new melanoma-selective drug delivery systems.