1569303-96-3

Basic information

• Product Name: 2-(3,4,5-trimethoxyphenylthio)benzoxazole
• CAS NO: 1569303-96-3
• Molecular Weight: 317.365
• Mol File: 1569303-96-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-(3,4,5-trimethoxyphenylthio)benzoxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3,4,5-trimethoxyphenylthio)benzoxazole(1569303-96-3)
• EPA Substance Registry System: 2-(3,4,5-trimethoxyphenylthio)benzoxazole(1569303-96-3)

Safety Data

• Hazardous Substances Data: 1569303-96-3(Hazardous Substances Data)

Upstream product

• 273-53-0 benzoxazole 
• 39614-62-5 3,4,5-trimethoxybenzenesulfonyl chloride 
• 1569303-99-6 3,4,5-trimethoxyphenylzinc bromide 
• 98555-60-3 2-benzoxazolesulfenyl chloride 
• 2382-96-9 2-sulfanyl-1,3-benzoxazole 

Relevant articles and documents

CuI promoted sulfenylation of organozinc reagents with arylsulfonyl chlorides

A CuI promoted sulfenylation of organozinc reagents with arylsulfonyl chlorides/PPh3 has been explored. This reaction proceeded smoothly through an alkyl/aryl radical (generated from organometallics) under mild conditions and produced the desired sulfide products in excellent yields.

Diaryl and heteroaryl sulfides: Synthesis via sulfenyl chlorides and evaluation as selective anti-breast-cancer agents

A mild protocol for the synthesis of diaryl and heteroaryl sulfides is described. In a one-pot procedure, thiols are converted to sulfenyl chlorides and reacted with arylzinc reagents. This method tolerates functional groups including aryl fluorides and chlorides, ketones, as well as N-heterocycles including pyrimidines, imidazoles, tetrazoles, and oxadiazoles. Two compounds synthesized by this method exhibited selective activity against the MCF-7 breast cancer cell line in the micromolar range.