1569352-16-4Relevant academic research and scientific papers
One-pot synthesis of coumarin-3-carboxamides containing a triazole ring via an isocyanide-based six-component reaction
Shaabani, Shabnam,Shaabani, Ahmad,Ng, Seik Weng
, p. 176 - 183 (2014/05/06)
A facile, efficient, and environmentally friendly approach has been developed for the diversity oriented synthesis of trifunctional coumarin-amide-triazole containing compounds. A wide variety of pharmacologically significant and structurally interesting compounds were synthesized via a one-pot, six-component, tandem Knoevenagel/Ugi/click reaction sequence from readily available starting materials in ethanol at room temperature in excellent overall yields. Substituents could be independently varied at five different positions.
