156945-36-7Relevant academic research and scientific papers
Development of a highly selective EP2-receptor agonist. Part 1: Identification of 16-hydroxy-17,17-trimethylene PGE2 derivatives
Tani, Kousuke,Naganawa, Atsushi,Ishida, Akiharu,Sagawa, Kenji,Harada, Hiroyuki,Ogawa, Mikio,Maruyama, Takayuki,Ohuchida, Shuichi,Nakai, Hisao,Kondo, Kigen,Toda, Masaaki
, p. 1093 - 1106 (2007/10/03)
Design and synthesis of an EP2-receptor selective agonist began with the chemical modification of α and ω-chains of butaprost 1a, which exhibits an affinity for the IP-receptor. Two series of prostaglandin (PG) analogues with a 16-hydroxy-17,17-trimethylene moiety as an ω-chain were identified. Among those tested, 4a,b,e,f,h and 6a,b,e,f,h were found to be highly selective EP2-receptor agonists. Structure activity relationships are discussed. Copyright
α,α-Cyclobisalkylation of aldehydes via ω-haloaldimines
Stevens, Christian V.,De Kimpe, Norbert G.,Katritzky, Alan R.
, p. 3763 - 3766 (2007/10/02)
The construction of a cycloalkyl ring at the α-position of aldehydes by cyclization of ω-haloaldimines is described. Alkylation of the corresponding aldimines with α,ω-dihaloalkanes followed by treatment with LDA results in a convenient access to α,α-cycl
