156977-40-1

Upstream product

• 156977-36-5 methyl 2-O-acetyl-3-O-benzyl-4,6-O-benzylidene-α-L-idopyranoside 
• 157085-40-0 methyl 3-O-benzyl-4,6-O-benzylidene-α-L-idopyranoside 
• 3162-96-7 methyl 4,6-O-benzylidene-α-L-idopyranoside 
• 256348-52-4 2,4,6-tri-O-acetyl-3-O-benzyl-L-idopyranosyl trichloroacetimidate 
• 241129-72-6 methyl 2,4,6-tri-O-acetyl-3-O-benzyl-α-L-idopyranoside 
• 241129-73-7 Acetic acid (4aS,6R,7R,8S,8aR)-8-benzyloxy-6-methoxy-2,2-dimethyl-hexahydro-pyrano[3,2-d][1,3]dioxin-7-yl ester 
• 181228-43-3 methyl 3-O-benzyl-4,6-O-isopropylidene-α-L-idopyranoside 
• 181228-42-2 methyl 3-O-benzyl-α-L-idopyranoside 
• 118711-49-2 1,2,4,6-tetra-O-acetyl-3-O-benzyl-L-idopyranoside 
• 156977-38-7 methyl 2-O-acetyl-3-O-benzyl-α-L-idopyranoside 

Downstream Products

• 156977-42-3 methyl (methyl 2-O-acetyl-3-O-benzyl-α-L-idopyranosid)uronate 
• 241129-75-9 (2R,3S,4S,5R,6R)-5-Acetoxy-3-((2R,3R,4R,5S,6R)-6-acetoxymethyl-3-azido-4-benzyloxy-5-carboxymethoxy-tetrahydro-pyran-2-yloxy)-4-benzyloxy-6-methoxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 241129-74-8 (2R,3S,4S,5R,6R)-5-Acetoxy-3-((2R,3R,4R,5S,6R)-6-acetoxymethyl-5-allyloxy-3-azido-4-benzyloxy-tetrahydro-pyran-2-yloxy)-4-benzyloxy-6-methoxy-tetrahydro-pyran-2-carboxylic acid methyl ester 
• 241129-85-1 (2R,3S,4S,5R,6R)-5-Acetoxy-3-[(2R,3R,4R,5S,6R)-6-acetoxymethyl-3-azido-4-benzyloxy-5-(2-oxo-ethoxy)-tetrahydro-pyran-2-yloxy]-4-benzyloxy-6-methoxy-tetrahydro-pyran-2-carboxylic acid methyl ester 

Relevant academic research and scientific papers

Synthesis and biological activity of oligomer-model compounds containing units of a key platelet-binding disaccharide of heparin

A key disaccharide unit in heparin, O-(2-deoxy-2-sulfamido-6-O-sulfo-α-D-glucopyranosyl)-(1→4)-2-O-sulfo-α-L-idop yranosyluronic acid, was previously found to be responsible for the binding interaction of heparin to platelets. A clustering effect to enhance the binding was found to be dependent on the number and frequency of the disaccharide units in a heparin molecule. To systematically examine the clustering effect, three oligomer-model compounds containing two or three units of the disaccharide were synthesized. These compounds inhibited 3H-labelled heparin binding to human platelets more strongly than a compound containing only one unit of the disaccharide.

Chemical Synthesis of Disaccharides which are Partial Structures of the Glycosaminoglycan Heparan Sulfate

A specific tetradecasaccharide sequence (oligo-H, 1) of the proteoglycan heparan sulfate has recently been identified as being responsible for binding and activation of the basic fibroplast growth factor (bFGF), a potent mitogen.We present here the first