156977-67-2

Basic information

• Product Name: tert-butyl (RS)-3-(benzyloxycarbonylmethyl)-1,2-thiazetidin-2-acetate 1,1-dioxide
• Synonyms: tert-butyl (RS)-3-(benzyloxycarbonylmethyl)-1,2-thiazetidin-2-acetate 1,1-dioxide
• CAS NO: 156977-67-2
• Molecular Weight: 369.439
• Mol File: 156977-67-2.mol

Chemical Properties

• CAS DataBase Reference: tert-butyl (RS)-3-(benzyloxycarbonylmethyl)-1,2-thiazetidin-2-acetate 1,1-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl (RS)-3-(benzyloxycarbonylmethyl)-1,2-thiazetidin-2-acetate 1,1-dioxide(156977-67-2)
• EPA Substance Registry System: tert-butyl (RS)-3-(benzyloxycarbonylmethyl)-1,2-thiazetidin-2-acetate 1,1-dioxide(156977-67-2)

Safety Data

• Hazardous Substances Data: 156977-67-2(Hazardous Substances Data)

Upstream product

• 4378-12-5 (RS)-3-amino-4-benzylthiobutyric acid 
• 5292-43-3 bromoacetic acid tert-butyl ester 
• 156977-58-1 benzyl (RS)-1,2-thiazetidin-3-acetate 1,1-dioxide 

Downstream Products

• 156977-75-2 tert-butyl <3-oxo-5-(phenylsulfinyl)-1,2-thiazinan-2-yl>acetate 1,1-dioxide 
• 156977-70-7 tert-butyl <3-<(phenylthio)carbonylmethyl>-1,2-thiazetidin-2-yl>acetate 1,1-dioxide 
• 156977-73-0 tert-butyl <3-oxo-5-(phenylthio)-1,2-thiazinan-2-yl>acetate 1,1-dioxide 

Relevant articles and documents

Substituted 1,2-Thiazetidine 1,1-Dioxides. Synthesis and Properties of N-Alkylated and N-Acylated Derivatives of 1,2-Thiazetidine-3-acetic Acid 1,1-Dioxide

1,2-Thiazetidine-3-acetic acid 1,1-dioxide was N-alkylated using bromoacetates, and N-acylated using either acyl chlorides, protected amino acid fluorides, or N-protected amino acid NCA, which seemed to be the most universal method. Most of the obtained "

Properties and Reactions of Substituted 1,2-Thiazetidine 1,1-Dioxides: Synthesis of 1,2-Thiazetidine-2,3-diacetic Acid Derivatives and Their Rearrangement to 1,2-Thiazinan-3-ones

β-Sultam-3-acetic acid ester 3 prepared from rac-S-benzyl-β-homocysteine is alkylated with bromoacetates yielding diacetates 9 which are transformed into the phenylthio esters 11.The thiazinanone derivatives 12 are obtained from 11 by rearrangement with lithium bis(trimethylsilyl)amide in excellent yields, and the syntheses of the derivatives 13, 14, and 15 are described.The stereochemistry of all products is elucidated by spectroscopic methods, and a reaction pathway is proposed.It is supported by the synthesis of the isomeric β-sultam-2,3-diacetate 20, which does not rearrange to a thiazinanone derivative.Some side reactions are described. - Key Words: β-Sultams / 1,2-Thiazetidine 1,1-dioxides / Thiazinanes